Ligustrazin increases lung cell autophagy and ameliorates paraquat-induced pulmonary fibrosis by inhibiting PI3K/Akt/mTOR and hedgehog signalling via increasing miR-193a expression

BACKGROUND: Reactive oxygen species (ROS) levels largely determine pulmonary fibrosis. Antioxidants have been found to ameliorate lung fibrosis after long-term paraquat (PQ) exposure. The effects of antioxidants, however, on the signalling pathways involved in PQ-induced lung fibrosis have not yet b...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Ming-wei, Su, Mei-xian, Tang, Deng-yun, Hao, Li, Xun, Xiang-Han, Huang, Yun-qiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371511/
https://www.ncbi.nlm.nih.gov/pubmed/30744607
http://dx.doi.org/10.1186/s12890-019-0799-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371511/
https://www.ncbi.nlm.nih.gov/pubmed/30744607
http://dx.doi.org/10.1186/s12890-019-0799-5

Ejemplares similares