Association of host immunity with Helicobacter pylori infection in recurrent gastric cancer

BACKGROUND: Helicobacter pylori infection is associated with the incidence of gastric cancer. Endoscopic resection has been developed as a proper technique to treat early stage of gastric cancer. However, some patients develop recurrent gastric cancer within 5 years after endoscopic treatment. The a...

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Autores principales: Sato, Mayu, Miura, Kou, Kageyama, Chihiro, Sakae, Hiroyuki, Obayashi, Yuka, Kawahara, Yoshiro, Matsushita, Osamu, Yokota, Kenji, Okada, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371572/
https://www.ncbi.nlm.nih.gov/pubmed/30792753
http://dx.doi.org/10.1186/s13027-019-0221-1
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author Sato, Mayu
Miura, Kou
Kageyama, Chihiro
Sakae, Hiroyuki
Obayashi, Yuka
Kawahara, Yoshiro
Matsushita, Osamu
Yokota, Kenji
Okada, Hiroyuki
author_facet Sato, Mayu
Miura, Kou
Kageyama, Chihiro
Sakae, Hiroyuki
Obayashi, Yuka
Kawahara, Yoshiro
Matsushita, Osamu
Yokota, Kenji
Okada, Hiroyuki
author_sort Sato, Mayu
collection PubMed
description BACKGROUND: Helicobacter pylori infection is associated with the incidence of gastric cancer. Endoscopic resection has been developed as a proper technique to treat early stage of gastric cancer. However, some patients develop recurrent gastric cancer within 5 years after endoscopic treatment. The aim of the present study is to explore a biomarker for detecting people who has high risk of gastric cancer recurrence. METHODS: We analyzed the Interleukin-10 (IL-10) single nucleotide polymorphism (SNP) and IgG subclass responses to the bacteria in patients with early gastric cancer and recurrent gastric cancer. RESULTS: Patients with hetero-type in the 1082 SNP and CC genotype in the 592 SNP were at high risk of recurrence of gastric cancer. In patients with genotype carrying high risk of recurrence, IgG1 level tended to be higher than that in patients with other genotypes. CONCLUSIONS: Dominance of T helper 2 (Th2) immunity controlled by IL-10 cytokine may be associated with H. pylori-associated gastric cancer recurrence.
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spelling pubmed-63715722019-02-21 Association of host immunity with Helicobacter pylori infection in recurrent gastric cancer Sato, Mayu Miura, Kou Kageyama, Chihiro Sakae, Hiroyuki Obayashi, Yuka Kawahara, Yoshiro Matsushita, Osamu Yokota, Kenji Okada, Hiroyuki Infect Agent Cancer Research Article BACKGROUND: Helicobacter pylori infection is associated with the incidence of gastric cancer. Endoscopic resection has been developed as a proper technique to treat early stage of gastric cancer. However, some patients develop recurrent gastric cancer within 5 years after endoscopic treatment. The aim of the present study is to explore a biomarker for detecting people who has high risk of gastric cancer recurrence. METHODS: We analyzed the Interleukin-10 (IL-10) single nucleotide polymorphism (SNP) and IgG subclass responses to the bacteria in patients with early gastric cancer and recurrent gastric cancer. RESULTS: Patients with hetero-type in the 1082 SNP and CC genotype in the 592 SNP were at high risk of recurrence of gastric cancer. In patients with genotype carrying high risk of recurrence, IgG1 level tended to be higher than that in patients with other genotypes. CONCLUSIONS: Dominance of T helper 2 (Th2) immunity controlled by IL-10 cytokine may be associated with H. pylori-associated gastric cancer recurrence. BioMed Central 2019-02-11 /pmc/articles/PMC6371572/ /pubmed/30792753 http://dx.doi.org/10.1186/s13027-019-0221-1 Text en © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Sato, Mayu
Miura, Kou
Kageyama, Chihiro
Sakae, Hiroyuki
Obayashi, Yuka
Kawahara, Yoshiro
Matsushita, Osamu
Yokota, Kenji
Okada, Hiroyuki
Association of host immunity with Helicobacter pylori infection in recurrent gastric cancer
title Association of host immunity with Helicobacter pylori infection in recurrent gastric cancer
title_full Association of host immunity with Helicobacter pylori infection in recurrent gastric cancer
title_fullStr Association of host immunity with Helicobacter pylori infection in recurrent gastric cancer
title_full_unstemmed Association of host immunity with Helicobacter pylori infection in recurrent gastric cancer
title_short Association of host immunity with Helicobacter pylori infection in recurrent gastric cancer
title_sort association of host immunity with helicobacter pylori infection in recurrent gastric cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371572/
https://www.ncbi.nlm.nih.gov/pubmed/30792753
http://dx.doi.org/10.1186/s13027-019-0221-1
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