Functions of the Heterologous Intron-Derived Fragments Intra and Extra Factor IX-cDNA Coding Region on the Human Factor IX Expression in HepG2 and Hek-293T Cells

BACKGROUND: Human FIX (hFIX) gene transfer into hepatocytes has provided a novel approach for treatment of hemophilia B. To obtain an improved expression of hFIX, the functional hFIX-expressing plasmids with appropriate intron-derived fragments which facilitate transcription and promote an efficient...

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Detalles Bibliográficos
Autores principales: Sam, Mohammad Reza, Zomorodipour, Alireza, Haddad-Mashadrizeh, Aliakbar, Ghorbani, Mahdi, Kardar, Gholam Ali, Sam, Sohrab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Institute of Genetic Engineering and Biotechnology 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371630/
https://www.ncbi.nlm.nih.gov/pubmed/30805387
http://dx.doi.org/10.21859/ijb.1753

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