Cargando…

Correlations of Twist Expression with Pathological and Computed Tomography (CT) Characteristics and Prognosis of Non-Small Cell Lung Cancer (NSCLC)

BACKGROUND: The aim of this study was to assess the correlations of Twist expression with pathological and computed tomography (CT) characteristics and prognosis of non-small cell lung cancer (NSCLC). MATERIAL/METHODS: We enrolled 120 patients with lung cancer who underwent CT examination. The Twist...

Descripción completa

Detalles Bibliográficos
Autores principales: Duan, Feng, Hao, Dapeng, Xu, Wenjian, Zhong, Xin, Luo, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371739/
https://www.ncbi.nlm.nih.gov/pubmed/30714578
http://dx.doi.org/10.12659/MSM.912674
_version_ 1783394623678316544
author Duan, Feng
Hao, Dapeng
Xu, Wenjian
Zhong, Xin
Luo, Tao
author_facet Duan, Feng
Hao, Dapeng
Xu, Wenjian
Zhong, Xin
Luo, Tao
author_sort Duan, Feng
collection PubMed
description BACKGROUND: The aim of this study was to assess the correlations of Twist expression with pathological and computed tomography (CT) characteristics and prognosis of non-small cell lung cancer (NSCLC). MATERIAL/METHODS: We enrolled 120 patients with lung cancer who underwent CT examination. The Twist protein expression level was detected in 120 cases of cancer tissues and a control group using immunohistochemical method. The survival curve was plotted using the Kaplan-Meier method and analyzed via log-rank test. RESULTS: The Twist expression was associated with tumor stage, differentiation degree, and presence or absence of lymph node metastasis, but had no correlations with sex, age, or histological type. Grade-3 bronchial involvement, pleural indentation, and hilar and mediastinal lymph node enlargement occurred more frequently in the high-expression Twist group compared with the low-expression Twist group. The overall survival rate of patients with Twist overexpression was significantly lower than that of patients with normal Twist expression. The mean survival time was 69.8 months in Twist protein expression-negative patients and 45.8 months in Twist protein expression-positive patients. Finally, the positive expression of Twist protein was significantly correlated with the long-term survival and prognosis of patients. CONCLUSIONS: The Twist gene might be involved in the occurrence and development of NSCLC, which is correlated with patient prognosis.
format Online
Article
Text
id pubmed-6371739
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher International Scientific Literature, Inc.
record_format MEDLINE/PubMed
spelling pubmed-63717392019-02-15 Correlations of Twist Expression with Pathological and Computed Tomography (CT) Characteristics and Prognosis of Non-Small Cell Lung Cancer (NSCLC) Duan, Feng Hao, Dapeng Xu, Wenjian Zhong, Xin Luo, Tao Med Sci Monit Clinical Research BACKGROUND: The aim of this study was to assess the correlations of Twist expression with pathological and computed tomography (CT) characteristics and prognosis of non-small cell lung cancer (NSCLC). MATERIAL/METHODS: We enrolled 120 patients with lung cancer who underwent CT examination. The Twist protein expression level was detected in 120 cases of cancer tissues and a control group using immunohistochemical method. The survival curve was plotted using the Kaplan-Meier method and analyzed via log-rank test. RESULTS: The Twist expression was associated with tumor stage, differentiation degree, and presence or absence of lymph node metastasis, but had no correlations with sex, age, or histological type. Grade-3 bronchial involvement, pleural indentation, and hilar and mediastinal lymph node enlargement occurred more frequently in the high-expression Twist group compared with the low-expression Twist group. The overall survival rate of patients with Twist overexpression was significantly lower than that of patients with normal Twist expression. The mean survival time was 69.8 months in Twist protein expression-negative patients and 45.8 months in Twist protein expression-positive patients. Finally, the positive expression of Twist protein was significantly correlated with the long-term survival and prognosis of patients. CONCLUSIONS: The Twist gene might be involved in the occurrence and development of NSCLC, which is correlated with patient prognosis. International Scientific Literature, Inc. 2019-02-04 /pmc/articles/PMC6371739/ /pubmed/30714578 http://dx.doi.org/10.12659/MSM.912674 Text en © Med Sci Monit, 2019 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Clinical Research
Duan, Feng
Hao, Dapeng
Xu, Wenjian
Zhong, Xin
Luo, Tao
Correlations of Twist Expression with Pathological and Computed Tomography (CT) Characteristics and Prognosis of Non-Small Cell Lung Cancer (NSCLC)
title Correlations of Twist Expression with Pathological and Computed Tomography (CT) Characteristics and Prognosis of Non-Small Cell Lung Cancer (NSCLC)
title_full Correlations of Twist Expression with Pathological and Computed Tomography (CT) Characteristics and Prognosis of Non-Small Cell Lung Cancer (NSCLC)
title_fullStr Correlations of Twist Expression with Pathological and Computed Tomography (CT) Characteristics and Prognosis of Non-Small Cell Lung Cancer (NSCLC)
title_full_unstemmed Correlations of Twist Expression with Pathological and Computed Tomography (CT) Characteristics and Prognosis of Non-Small Cell Lung Cancer (NSCLC)
title_short Correlations of Twist Expression with Pathological and Computed Tomography (CT) Characteristics and Prognosis of Non-Small Cell Lung Cancer (NSCLC)
title_sort correlations of twist expression with pathological and computed tomography (ct) characteristics and prognosis of non-small cell lung cancer (nsclc)
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371739/
https://www.ncbi.nlm.nih.gov/pubmed/30714578
http://dx.doi.org/10.12659/MSM.912674
work_keys_str_mv AT duanfeng correlationsoftwistexpressionwithpathologicalandcomputedtomographyctcharacteristicsandprognosisofnonsmallcelllungcancernsclc
AT haodapeng correlationsoftwistexpressionwithpathologicalandcomputedtomographyctcharacteristicsandprognosisofnonsmallcelllungcancernsclc
AT xuwenjian correlationsoftwistexpressionwithpathologicalandcomputedtomographyctcharacteristicsandprognosisofnonsmallcelllungcancernsclc
AT zhongxin correlationsoftwistexpressionwithpathologicalandcomputedtomographyctcharacteristicsandprognosisofnonsmallcelllungcancernsclc
AT luotao correlationsoftwistexpressionwithpathologicalandcomputedtomographyctcharacteristicsandprognosisofnonsmallcelllungcancernsclc