Cargando…
Correlations of Twist Expression with Pathological and Computed Tomography (CT) Characteristics and Prognosis of Non-Small Cell Lung Cancer (NSCLC)
BACKGROUND: The aim of this study was to assess the correlations of Twist expression with pathological and computed tomography (CT) characteristics and prognosis of non-small cell lung cancer (NSCLC). MATERIAL/METHODS: We enrolled 120 patients with lung cancer who underwent CT examination. The Twist...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371739/ https://www.ncbi.nlm.nih.gov/pubmed/30714578 http://dx.doi.org/10.12659/MSM.912674 |
_version_ | 1783394623678316544 |
---|---|
author | Duan, Feng Hao, Dapeng Xu, Wenjian Zhong, Xin Luo, Tao |
author_facet | Duan, Feng Hao, Dapeng Xu, Wenjian Zhong, Xin Luo, Tao |
author_sort | Duan, Feng |
collection | PubMed |
description | BACKGROUND: The aim of this study was to assess the correlations of Twist expression with pathological and computed tomography (CT) characteristics and prognosis of non-small cell lung cancer (NSCLC). MATERIAL/METHODS: We enrolled 120 patients with lung cancer who underwent CT examination. The Twist protein expression level was detected in 120 cases of cancer tissues and a control group using immunohistochemical method. The survival curve was plotted using the Kaplan-Meier method and analyzed via log-rank test. RESULTS: The Twist expression was associated with tumor stage, differentiation degree, and presence or absence of lymph node metastasis, but had no correlations with sex, age, or histological type. Grade-3 bronchial involvement, pleural indentation, and hilar and mediastinal lymph node enlargement occurred more frequently in the high-expression Twist group compared with the low-expression Twist group. The overall survival rate of patients with Twist overexpression was significantly lower than that of patients with normal Twist expression. The mean survival time was 69.8 months in Twist protein expression-negative patients and 45.8 months in Twist protein expression-positive patients. Finally, the positive expression of Twist protein was significantly correlated with the long-term survival and prognosis of patients. CONCLUSIONS: The Twist gene might be involved in the occurrence and development of NSCLC, which is correlated with patient prognosis. |
format | Online Article Text |
id | pubmed-6371739 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-63717392019-02-15 Correlations of Twist Expression with Pathological and Computed Tomography (CT) Characteristics and Prognosis of Non-Small Cell Lung Cancer (NSCLC) Duan, Feng Hao, Dapeng Xu, Wenjian Zhong, Xin Luo, Tao Med Sci Monit Clinical Research BACKGROUND: The aim of this study was to assess the correlations of Twist expression with pathological and computed tomography (CT) characteristics and prognosis of non-small cell lung cancer (NSCLC). MATERIAL/METHODS: We enrolled 120 patients with lung cancer who underwent CT examination. The Twist protein expression level was detected in 120 cases of cancer tissues and a control group using immunohistochemical method. The survival curve was plotted using the Kaplan-Meier method and analyzed via log-rank test. RESULTS: The Twist expression was associated with tumor stage, differentiation degree, and presence or absence of lymph node metastasis, but had no correlations with sex, age, or histological type. Grade-3 bronchial involvement, pleural indentation, and hilar and mediastinal lymph node enlargement occurred more frequently in the high-expression Twist group compared with the low-expression Twist group. The overall survival rate of patients with Twist overexpression was significantly lower than that of patients with normal Twist expression. The mean survival time was 69.8 months in Twist protein expression-negative patients and 45.8 months in Twist protein expression-positive patients. Finally, the positive expression of Twist protein was significantly correlated with the long-term survival and prognosis of patients. CONCLUSIONS: The Twist gene might be involved in the occurrence and development of NSCLC, which is correlated with patient prognosis. International Scientific Literature, Inc. 2019-02-04 /pmc/articles/PMC6371739/ /pubmed/30714578 http://dx.doi.org/10.12659/MSM.912674 Text en © Med Sci Monit, 2019 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) ) |
spellingShingle | Clinical Research Duan, Feng Hao, Dapeng Xu, Wenjian Zhong, Xin Luo, Tao Correlations of Twist Expression with Pathological and Computed Tomography (CT) Characteristics and Prognosis of Non-Small Cell Lung Cancer (NSCLC) |
title | Correlations of Twist Expression with Pathological and Computed Tomography (CT) Characteristics and Prognosis of Non-Small Cell Lung Cancer (NSCLC) |
title_full | Correlations of Twist Expression with Pathological and Computed Tomography (CT) Characteristics and Prognosis of Non-Small Cell Lung Cancer (NSCLC) |
title_fullStr | Correlations of Twist Expression with Pathological and Computed Tomography (CT) Characteristics and Prognosis of Non-Small Cell Lung Cancer (NSCLC) |
title_full_unstemmed | Correlations of Twist Expression with Pathological and Computed Tomography (CT) Characteristics and Prognosis of Non-Small Cell Lung Cancer (NSCLC) |
title_short | Correlations of Twist Expression with Pathological and Computed Tomography (CT) Characteristics and Prognosis of Non-Small Cell Lung Cancer (NSCLC) |
title_sort | correlations of twist expression with pathological and computed tomography (ct) characteristics and prognosis of non-small cell lung cancer (nsclc) |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371739/ https://www.ncbi.nlm.nih.gov/pubmed/30714578 http://dx.doi.org/10.12659/MSM.912674 |
work_keys_str_mv | AT duanfeng correlationsoftwistexpressionwithpathologicalandcomputedtomographyctcharacteristicsandprognosisofnonsmallcelllungcancernsclc AT haodapeng correlationsoftwistexpressionwithpathologicalandcomputedtomographyctcharacteristicsandprognosisofnonsmallcelllungcancernsclc AT xuwenjian correlationsoftwistexpressionwithpathologicalandcomputedtomographyctcharacteristicsandprognosisofnonsmallcelllungcancernsclc AT zhongxin correlationsoftwistexpressionwithpathologicalandcomputedtomographyctcharacteristicsandprognosisofnonsmallcelllungcancernsclc AT luotao correlationsoftwistexpressionwithpathologicalandcomputedtomographyctcharacteristicsandprognosisofnonsmallcelllungcancernsclc |