Mitochondrial Stress-Initiated Aberrant Activation of the NLRP3 Inflammasome Regulates the Functional Deterioration of Hematopoietic Stem Cell Aging

Aging-associated defects in hematopoietic stem cells (HSCs) can manifest in their progeny, leading to aberrant activation of the NLRP3 inflammasome in macrophages and affecting distant tissues and organismal health span. Whether the NLRP3 inflammasome is aberrantly activated in HSCs during physiolog...

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Detalles Bibliográficos
Autores principales: Luo, Hanzhi, Mu, Wei-Chieh, Karki, Rajendra, Chiang, Hou-Hsien, Mohrin, Mary, Shin, Jiyung J., Ohkubo, Rika, Ito, Keisuke, Kanneganti, Thirumala-Devi, Chen, Danica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371804/
https://www.ncbi.nlm.nih.gov/pubmed/30673616
http://dx.doi.org/10.1016/j.celrep.2018.12.101

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