Synergistic action of dual IGF1/R and MEK inhibition sensitizes childhood acute lymphoblastic leukemia (ALL) cells to cytotoxic agents and involves downregulation of STAT6 and PDAP1

Heterogeneous upregulation of multiple prosurvival pathways underlies resistance to damage-induced apoptosis in acute lymphoblastic leukemia (ALL) cells despite normal p53 responses. Here, we show that the dual combination of insulin-like growth factor 1 (IGF1)/IGF1 receptor (IGF1/R) and mitogen-act...

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Detalles Bibliográficos
Autores principales: Weston, Victoria J., Wei, Wenbin, Stankovic, Tatjana, Kearns, Pamela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Inc 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371922/
https://www.ncbi.nlm.nih.gov/pubmed/29656114
http://dx.doi.org/10.1016/j.exphem.2018.04.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371922/
https://www.ncbi.nlm.nih.gov/pubmed/29656114
http://dx.doi.org/10.1016/j.exphem.2018.04.002

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