Age- and disease-dependent increase of the mitophagy marker phospho-ubiquitin in normal aging and Lewy body disease

Although exact causes of Parkinson disease (PD) remain enigmatic, mitochondrial dysfunction is increasingly appreciated as a key determinant of dopaminergic neuron susceptibility in both familial and sporadic PD. Two genes associated with recessive, early-onset PD encode the ubiquitin (Ub) kinase PI...

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Detalles Bibliográficos
Autores principales: Hou, Xu, Fiesel, Fabienne C., Truban, Dominika, Castanedes Casey, Monica, Lin, Wen-lang, Soto, Alexandra I., Tacik, Pawel, Rousseau, Linda G., Diehl, Nancy N., Heckman, Michael G., Lorenzo-Betancor, Oswaldo, Ferrer, Isidre, Arbelo, José M., Steele, John C., Farrer, Matthew J., Cornejo-Olivas, Mario, Torres, Luis, Mata, Ignacio F., Graff-Radford, Neill R., Wszolek, Zbigniew K., Ross, Owen A., Murray, Melissa E., Dickson, Dennis W., Springer, Wolfdieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Research Paper - Translational
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372017/
https://www.ncbi.nlm.nih.gov/pubmed/29947276
http://dx.doi.org/10.1080/15548627.2018.1461294

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