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Logic Regression Analysis of Gene Polymorphisms and HDL Levels in a Nationally Representative Sample of Iranian Adolescents: The CASPIAN-III Study
BACKGROUND: To investigate the associations of genetic polymorphism with high-density lipoprotein-cholesterol (HDL-C) levels in Iranian adolescents. METHODS: This multicentre study was conducted on 10 - 18 year-old students from 27 provinces in Iran. Logic regression approach was used to determine t...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Kowsar
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372018/ https://www.ncbi.nlm.nih.gov/pubmed/30805016 http://dx.doi.org/10.5812/ijem.14037 |
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author | Moghadasi, Mehri Kelishadi, Roya Marateb, Hamid Reza Haghjooy Javanmard, Shaghayegh Mansourian, Marjan Heshmat, Ramin Esmaeil Motlagh, Mohammad |
author_facet | Moghadasi, Mehri Kelishadi, Roya Marateb, Hamid Reza Haghjooy Javanmard, Shaghayegh Mansourian, Marjan Heshmat, Ramin Esmaeil Motlagh, Mohammad |
author_sort | Moghadasi, Mehri |
collection | PubMed |
description | BACKGROUND: To investigate the associations of genetic polymorphism with high-density lipoprotein-cholesterol (HDL-C) levels in Iranian adolescents. METHODS: This multicentre study was conducted on 10 - 18 year-old students from 27 provinces in Iran. Logic regression approach was used to determine the main effects and interactions of polymorphisms related to HDL-C levels. RESULTS: The rs708272 polymorphism was significantly related to HDL-C levels. Moreover, rs708272 increased HDL-C levels and had a protective effect on HDL-C. The interaction of rs2230808 and rs5880 polymorphisms as well as the interaction of rs320 and rs708272 polymorphisms were associated with lower HDL-C levels. Furthermore, the interaction of rs320 and rs1801177 polymorphisms was associated with lower HDL-C levels. CONCLUSIONS: We found that not only single SNPs, but also interactions of several SNPs affect HDL-C levels. Given the high prevalence of low HDL-C in Middle Eastern populations, further genetic studies are required for detailed analysis. |
format | Online Article Text |
id | pubmed-6372018 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Kowsar |
record_format | MEDLINE/PubMed |
spelling | pubmed-63720182019-02-25 Logic Regression Analysis of Gene Polymorphisms and HDL Levels in a Nationally Representative Sample of Iranian Adolescents: The CASPIAN-III Study Moghadasi, Mehri Kelishadi, Roya Marateb, Hamid Reza Haghjooy Javanmard, Shaghayegh Mansourian, Marjan Heshmat, Ramin Esmaeil Motlagh, Mohammad Int J Endocrinol Metab Research Article BACKGROUND: To investigate the associations of genetic polymorphism with high-density lipoprotein-cholesterol (HDL-C) levels in Iranian adolescents. METHODS: This multicentre study was conducted on 10 - 18 year-old students from 27 provinces in Iran. Logic regression approach was used to determine the main effects and interactions of polymorphisms related to HDL-C levels. RESULTS: The rs708272 polymorphism was significantly related to HDL-C levels. Moreover, rs708272 increased HDL-C levels and had a protective effect on HDL-C. The interaction of rs2230808 and rs5880 polymorphisms as well as the interaction of rs320 and rs708272 polymorphisms were associated with lower HDL-C levels. Furthermore, the interaction of rs320 and rs1801177 polymorphisms was associated with lower HDL-C levels. CONCLUSIONS: We found that not only single SNPs, but also interactions of several SNPs affect HDL-C levels. Given the high prevalence of low HDL-C in Middle Eastern populations, further genetic studies are required for detailed analysis. Kowsar 2017-07-29 /pmc/articles/PMC6372018/ /pubmed/30805016 http://dx.doi.org/10.5812/ijem.14037 Text en Copyright © 2017, International Journal of Endocrinology and Metabolism http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited. |
spellingShingle | Research Article Moghadasi, Mehri Kelishadi, Roya Marateb, Hamid Reza Haghjooy Javanmard, Shaghayegh Mansourian, Marjan Heshmat, Ramin Esmaeil Motlagh, Mohammad Logic Regression Analysis of Gene Polymorphisms and HDL Levels in a Nationally Representative Sample of Iranian Adolescents: The CASPIAN-III Study |
title | Logic Regression Analysis of Gene Polymorphisms and HDL Levels in a Nationally Representative Sample of Iranian Adolescents: The CASPIAN-III Study |
title_full | Logic Regression Analysis of Gene Polymorphisms and HDL Levels in a Nationally Representative Sample of Iranian Adolescents: The CASPIAN-III Study |
title_fullStr | Logic Regression Analysis of Gene Polymorphisms and HDL Levels in a Nationally Representative Sample of Iranian Adolescents: The CASPIAN-III Study |
title_full_unstemmed | Logic Regression Analysis of Gene Polymorphisms and HDL Levels in a Nationally Representative Sample of Iranian Adolescents: The CASPIAN-III Study |
title_short | Logic Regression Analysis of Gene Polymorphisms and HDL Levels in a Nationally Representative Sample of Iranian Adolescents: The CASPIAN-III Study |
title_sort | logic regression analysis of gene polymorphisms and hdl levels in a nationally representative sample of iranian adolescents: the caspian-iii study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372018/ https://www.ncbi.nlm.nih.gov/pubmed/30805016 http://dx.doi.org/10.5812/ijem.14037 |
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