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Logic Regression Analysis of Gene Polymorphisms and HDL Levels in a Nationally Representative Sample of Iranian Adolescents: The CASPIAN-III Study

BACKGROUND: To investigate the associations of genetic polymorphism with high-density lipoprotein-cholesterol (HDL-C) levels in Iranian adolescents. METHODS: This multicentre study was conducted on 10 - 18 year-old students from 27 provinces in Iran. Logic regression approach was used to determine t...

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Autores principales: Moghadasi, Mehri, Kelishadi, Roya, Marateb, Hamid Reza, Haghjooy Javanmard, Shaghayegh, Mansourian, Marjan, Heshmat, Ramin, Esmaeil Motlagh, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kowsar 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372018/
https://www.ncbi.nlm.nih.gov/pubmed/30805016
http://dx.doi.org/10.5812/ijem.14037
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author Moghadasi, Mehri
Kelishadi, Roya
Marateb, Hamid Reza
Haghjooy Javanmard, Shaghayegh
Mansourian, Marjan
Heshmat, Ramin
Esmaeil Motlagh, Mohammad
author_facet Moghadasi, Mehri
Kelishadi, Roya
Marateb, Hamid Reza
Haghjooy Javanmard, Shaghayegh
Mansourian, Marjan
Heshmat, Ramin
Esmaeil Motlagh, Mohammad
author_sort Moghadasi, Mehri
collection PubMed
description BACKGROUND: To investigate the associations of genetic polymorphism with high-density lipoprotein-cholesterol (HDL-C) levels in Iranian adolescents. METHODS: This multicentre study was conducted on 10 - 18 year-old students from 27 provinces in Iran. Logic regression approach was used to determine the main effects and interactions of polymorphisms related to HDL-C levels. RESULTS: The rs708272 polymorphism was significantly related to HDL-C levels. Moreover, rs708272 increased HDL-C levels and had a protective effect on HDL-C. The interaction of rs2230808 and rs5880 polymorphisms as well as the interaction of rs320 and rs708272 polymorphisms were associated with lower HDL-C levels. Furthermore, the interaction of rs320 and rs1801177 polymorphisms was associated with lower HDL-C levels. CONCLUSIONS: We found that not only single SNPs, but also interactions of several SNPs affect HDL-C levels. Given the high prevalence of low HDL-C in Middle Eastern populations, further genetic studies are required for detailed analysis.
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spelling pubmed-63720182019-02-25 Logic Regression Analysis of Gene Polymorphisms and HDL Levels in a Nationally Representative Sample of Iranian Adolescents: The CASPIAN-III Study Moghadasi, Mehri Kelishadi, Roya Marateb, Hamid Reza Haghjooy Javanmard, Shaghayegh Mansourian, Marjan Heshmat, Ramin Esmaeil Motlagh, Mohammad Int J Endocrinol Metab Research Article BACKGROUND: To investigate the associations of genetic polymorphism with high-density lipoprotein-cholesterol (HDL-C) levels in Iranian adolescents. METHODS: This multicentre study was conducted on 10 - 18 year-old students from 27 provinces in Iran. Logic regression approach was used to determine the main effects and interactions of polymorphisms related to HDL-C levels. RESULTS: The rs708272 polymorphism was significantly related to HDL-C levels. Moreover, rs708272 increased HDL-C levels and had a protective effect on HDL-C. The interaction of rs2230808 and rs5880 polymorphisms as well as the interaction of rs320 and rs708272 polymorphisms were associated with lower HDL-C levels. Furthermore, the interaction of rs320 and rs1801177 polymorphisms was associated with lower HDL-C levels. CONCLUSIONS: We found that not only single SNPs, but also interactions of several SNPs affect HDL-C levels. Given the high prevalence of low HDL-C in Middle Eastern populations, further genetic studies are required for detailed analysis. Kowsar 2017-07-29 /pmc/articles/PMC6372018/ /pubmed/30805016 http://dx.doi.org/10.5812/ijem.14037 Text en Copyright © 2017, International Journal of Endocrinology and Metabolism http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
spellingShingle Research Article
Moghadasi, Mehri
Kelishadi, Roya
Marateb, Hamid Reza
Haghjooy Javanmard, Shaghayegh
Mansourian, Marjan
Heshmat, Ramin
Esmaeil Motlagh, Mohammad
Logic Regression Analysis of Gene Polymorphisms and HDL Levels in a Nationally Representative Sample of Iranian Adolescents: The CASPIAN-III Study
title Logic Regression Analysis of Gene Polymorphisms and HDL Levels in a Nationally Representative Sample of Iranian Adolescents: The CASPIAN-III Study
title_full Logic Regression Analysis of Gene Polymorphisms and HDL Levels in a Nationally Representative Sample of Iranian Adolescents: The CASPIAN-III Study
title_fullStr Logic Regression Analysis of Gene Polymorphisms and HDL Levels in a Nationally Representative Sample of Iranian Adolescents: The CASPIAN-III Study
title_full_unstemmed Logic Regression Analysis of Gene Polymorphisms and HDL Levels in a Nationally Representative Sample of Iranian Adolescents: The CASPIAN-III Study
title_short Logic Regression Analysis of Gene Polymorphisms and HDL Levels in a Nationally Representative Sample of Iranian Adolescents: The CASPIAN-III Study
title_sort logic regression analysis of gene polymorphisms and hdl levels in a nationally representative sample of iranian adolescents: the caspian-iii study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372018/
https://www.ncbi.nlm.nih.gov/pubmed/30805016
http://dx.doi.org/10.5812/ijem.14037
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