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Hepatocyte-specific lysosomal acid lipase deficiency protects mice from diet-induced obesity but promotes hepatic inflammation

Lysosomal acid lipase (LAL) hydrolyzes cholesteryl esters (CE) and triglycerides (TG) to generate fatty acids (FA) and cholesterol. LAL deficiency (LAL-D) in both humans and mice leads to hepatomegaly, hypercholesterolemia, and shortened life span. Despite its essential role in lysosomal neutral lip...

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Detalles Bibliográficos
Autores principales:	Leopold, Christina, Duta-Mare, Madalina, Sachdev, Vinay, Goeritzer, Madeleine, Maresch, Lisa Katharina, Kolb, Dagmar, Reicher, Helga, Wagner, Bettina, Stojakovic, Tatjana, Ruelicke, Thomas, Haemmerle, Guenter, Hoefler, Gerald, Sattler, Wolfgang, Kratky, Dagmar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372077/ https://www.ncbi.nlm.nih.gov/pubmed/30639734 http://dx.doi.org/10.1016/j.bbalip.2019.01.007

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