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A head mounted device stimulator for optogenetic retinal prosthesis

Objective. Our main objective is to demonstrate that compact high radiance gallium nitride displays can be used with conventional virtual reality optics to stimulate an optogenetic retina. Hence, we aim to introduce a non-invasive approach to restore vision for people with conditions such as retinit...

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Autores principales: Soltan, Ahmed, Barrett, John Martin, Maaskant, Pleun, Armstrong, Niall, Al-Atabany, Walid, Chaudet, Lionel, Neil, Mark, Sernagor, Evelyne, Degenaar, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOP Publishing 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372131/
https://www.ncbi.nlm.nih.gov/pubmed/30156188
http://dx.doi.org/10.1088/1741-2552/aadd55
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author Soltan, Ahmed
Barrett, John Martin
Maaskant, Pleun
Armstrong, Niall
Al-Atabany, Walid
Chaudet, Lionel
Neil, Mark
Sernagor, Evelyne
Degenaar, Patrick
author_facet Soltan, Ahmed
Barrett, John Martin
Maaskant, Pleun
Armstrong, Niall
Al-Atabany, Walid
Chaudet, Lionel
Neil, Mark
Sernagor, Evelyne
Degenaar, Patrick
author_sort Soltan, Ahmed
collection PubMed
description Objective. Our main objective is to demonstrate that compact high radiance gallium nitride displays can be used with conventional virtual reality optics to stimulate an optogenetic retina. Hence, we aim to introduce a non-invasive approach to restore vision for people with conditions such as retinitis pigmentosa where there is a remaining viable communication link between the retina and the visual cortex. Approach. We design and implement the headset using a high-density µLED matrix, Raspberry Pi, microcontroller from NXP and virtual reality lens. Then, a test platform is developed to evaluate the performance of the headset and the optical system. Furthermore, image simplification algorithms are used to simplify the scene to be sent to the retina. Moreover, in vivo evaluation of the genetically modified retina response at different light intensity is discussed to prove the reliability of the proposed system. Main results. We demonstrate that in keeping with regulatory guidance, the headset displays need to limit their luminance to 90 kcd m(−2). We demonstrate an optical system with 5.75% efficiency which allows for 0.16 mW mm(−2) irradiance on the retina within the regulatory guidance, but which is capable of an average peak irradiance of 1.35 mW mm(−2). As this is lower than the commonly accepted threshold for channelrhodopsin-2, we demonstrate efficacy through an optical model of an eye onto a biological retina. Significance. We demonstrate a fully functional 8100-pixel headset system including software/hardware which can operate on a standard consumer battery for periods exceeding a 24 h recharge cycle. The headset is capable of delivering enough light to stimulate the genetically modified retina cells and also keeping the amount of light below the regulation threshold for safety.
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spelling pubmed-63721312019-02-20 A head mounted device stimulator for optogenetic retinal prosthesis Soltan, Ahmed Barrett, John Martin Maaskant, Pleun Armstrong, Niall Al-Atabany, Walid Chaudet, Lionel Neil, Mark Sernagor, Evelyne Degenaar, Patrick J Neural Eng Paper Objective. Our main objective is to demonstrate that compact high radiance gallium nitride displays can be used with conventional virtual reality optics to stimulate an optogenetic retina. Hence, we aim to introduce a non-invasive approach to restore vision for people with conditions such as retinitis pigmentosa where there is a remaining viable communication link between the retina and the visual cortex. Approach. We design and implement the headset using a high-density µLED matrix, Raspberry Pi, microcontroller from NXP and virtual reality lens. Then, a test platform is developed to evaluate the performance of the headset and the optical system. Furthermore, image simplification algorithms are used to simplify the scene to be sent to the retina. Moreover, in vivo evaluation of the genetically modified retina response at different light intensity is discussed to prove the reliability of the proposed system. Main results. We demonstrate that in keeping with regulatory guidance, the headset displays need to limit their luminance to 90 kcd m(−2). We demonstrate an optical system with 5.75% efficiency which allows for 0.16 mW mm(−2) irradiance on the retina within the regulatory guidance, but which is capable of an average peak irradiance of 1.35 mW mm(−2). As this is lower than the commonly accepted threshold for channelrhodopsin-2, we demonstrate efficacy through an optical model of an eye onto a biological retina. Significance. We demonstrate a fully functional 8100-pixel headset system including software/hardware which can operate on a standard consumer battery for periods exceeding a 24 h recharge cycle. The headset is capable of delivering enough light to stimulate the genetically modified retina cells and also keeping the amount of light below the regulation threshold for safety. IOP Publishing 2018-12 2018-10-09 /pmc/articles/PMC6372131/ /pubmed/30156188 http://dx.doi.org/10.1088/1741-2552/aadd55 Text en © 2018 IOP Publishing Ltd http://creativecommons.org/licenses/by/3.0/ Original content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence (http://creativecommons.org/licenses/by/3.0) . Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.
spellingShingle Paper
Soltan, Ahmed
Barrett, John Martin
Maaskant, Pleun
Armstrong, Niall
Al-Atabany, Walid
Chaudet, Lionel
Neil, Mark
Sernagor, Evelyne
Degenaar, Patrick
A head mounted device stimulator for optogenetic retinal prosthesis
title A head mounted device stimulator for optogenetic retinal prosthesis
title_full A head mounted device stimulator for optogenetic retinal prosthesis
title_fullStr A head mounted device stimulator for optogenetic retinal prosthesis
title_full_unstemmed A head mounted device stimulator for optogenetic retinal prosthesis
title_short A head mounted device stimulator for optogenetic retinal prosthesis
title_sort head mounted device stimulator for optogenetic retinal prosthesis
topic Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372131/
https://www.ncbi.nlm.nih.gov/pubmed/30156188
http://dx.doi.org/10.1088/1741-2552/aadd55
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