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The ability of locked nucleic acid oligonucleotides to pre-structure the double helix: A molecular simulation and binding study

Locked nucleic acid (LNA) oligonucleotides bind DNA target sequences forming Watson-Crick and Hoogsteen base pairs, and are therefore of interest for medical applications. To be biologically active, such an oligonucleotide has to efficiently bind the target sequence. Here we used molecular dynamics...

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Detalles Bibliográficos
Autores principales:	Xu, You, Gissberg, Olof, Pabon-Martinez, Y. Vladimir, Wengel, Jesper, Lundin, Karin E., Smith, C. I. Edvard, Zain, Rula, Nilsson, Lennart, Villa, Alessandra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372149/ https://www.ncbi.nlm.nih.gov/pubmed/30753192 http://dx.doi.org/10.1371/journal.pone.0211651

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