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Novel site-specific PEGylated L-asparaginase

L-asparaginase (ASNase) from Escherichia coli is currently used in some countries in its PEGylated form (ONCASPAR, pegaspargase) to treat acute lymphoblastic leukemia (ALL). PEGylation refers to the covalent attachment of poly(ethylene) glycol to the protein drug and it not only reduces the immune s...

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Detalles Bibliográficos
Autores principales:	Meneguetti, Giovanna Pastore, Santos, João Henrique Picado Madalena, Obreque, Karin Mariana Torres, Barbosa, Christiano Marcello Vaz, Monteiro, Gisele, Farsky, Sandra Helena Poliselli, Marim de Oliveira, Adriano, Angeli, Claudia Blanes, Palmisano, Giuseppe, Ventura, Sónia Patrícia Marques, Pessoa-Junior, Adalberto, de Oliveira Rangel-Yagui, Carlota
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372183/ https://www.ncbi.nlm.nih.gov/pubmed/30753228 http://dx.doi.org/10.1371/journal.pone.0211951

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