Induction of oxidative stress, apoptosis and DNA damage by koumine in Tetrahymena thermophila

Koumine is a component of the Chinese medicinal herb Gelsemium elegans and is toxic to vertebrates. We used the ciliate Tetrahymena thermophila as a model to evaluate the toxic effects of this indole alkaloid in eukaryotic microorganisms. Koumine inhibited T. thermophila growth and viability in a do...

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Detalles Bibliográficos
Autores principales: Ye, Qiao, Zhang, Chaonan, Wang, Zhenlu, Feng, Yongyong, Zhou, Aiguo, Xie, Shaolin, Xiang, Qiong, Song, Enfeng, Zou, Jixing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372211/
https://www.ncbi.nlm.nih.gov/pubmed/30753239
http://dx.doi.org/10.1371/journal.pone.0212231

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372211/
https://www.ncbi.nlm.nih.gov/pubmed/30753239
http://dx.doi.org/10.1371/journal.pone.0212231

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