Cargando…

A Decade in Psychiatric GWAS Research

After more than ten years of accumulated efforts, genome-wide association studies (GWAS) have led to many findings, most of which have been deposited into the GWAS Catalog. Between GWAS’s inception and March 2017, the GWAS Catalog has collected 2,430 studies, 1,818 phenotypes, and 28,462 associated...

Descripción completa

Detalles Bibliográficos
Autores principales: Horwitz, Tanya, Lam, Katie, Chen, Yu, Xia, Yan, Liu, Chunyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372350/
https://www.ncbi.nlm.nih.gov/pubmed/29942042
http://dx.doi.org/10.1038/s41380-018-0055-z
_version_ 1783394716150136832
author Horwitz, Tanya
Lam, Katie
Chen, Yu
Xia, Yan
Liu, Chunyu
author_facet Horwitz, Tanya
Lam, Katie
Chen, Yu
Xia, Yan
Liu, Chunyu
author_sort Horwitz, Tanya
collection PubMed
description After more than ten years of accumulated efforts, genome-wide association studies (GWAS) have led to many findings, most of which have been deposited into the GWAS Catalog. Between GWAS’s inception and March 2017, the GWAS Catalog has collected 2,430 studies, 1,818 phenotypes, and 28,462 associated SNPs. We reclassified the psychology-related phenotypes into 198 reclassified phenotypes, which accounted for 472 studies and 6,632 SNPs. In total, 1,109 of the SNPs reached genome-wide significance. Of these, 133 were replicated for the same psychological trait in different studies. Another 379 SNPs were replicated within one original study. The SNPs rs2075650 and rs4420638 were linked to the most replications within a single reclassified phenotype; both were associated with Alzheimer’s disease (AD). Schizophrenia was associated with 76 SNPs. Alzheimer’s disease and schizophrenia were linked to many physical phenotypes, including cholesterol and body mass index, through common GWAS signals. Alzheimer’s disease also shared risk SNPs with age-related phenotypes such as age-related macular degeneration and longevity. Smoking-related SNPs were linked to lung cancer and respiratory function. Alcohol-related SNPs were associated with cardiovascular and digestive system phenotypes and disorders. Two separate studies also identified a shared risk SNP for bipolar disorder and educational attainment. This review revealed a list of reproducible SNPs worthy of future functional investigation. Additionally, by identifying SNPs associated with multiple phenotypes, we illustrated the importance of studying the relationships among phenotypes to resolve the nature of their causal links. The insights within this review will hopefully pave the way for future evidence-based genetic studies.
format Online
Article
Text
id pubmed-6372350
institution National Center for Biotechnology Information
language English
publishDate 2018
record_format MEDLINE/PubMed
spelling pubmed-63723502019-02-12 A Decade in Psychiatric GWAS Research Horwitz, Tanya Lam, Katie Chen, Yu Xia, Yan Liu, Chunyu Mol Psychiatry Article After more than ten years of accumulated efforts, genome-wide association studies (GWAS) have led to many findings, most of which have been deposited into the GWAS Catalog. Between GWAS’s inception and March 2017, the GWAS Catalog has collected 2,430 studies, 1,818 phenotypes, and 28,462 associated SNPs. We reclassified the psychology-related phenotypes into 198 reclassified phenotypes, which accounted for 472 studies and 6,632 SNPs. In total, 1,109 of the SNPs reached genome-wide significance. Of these, 133 were replicated for the same psychological trait in different studies. Another 379 SNPs were replicated within one original study. The SNPs rs2075650 and rs4420638 were linked to the most replications within a single reclassified phenotype; both were associated with Alzheimer’s disease (AD). Schizophrenia was associated with 76 SNPs. Alzheimer’s disease and schizophrenia were linked to many physical phenotypes, including cholesterol and body mass index, through common GWAS signals. Alzheimer’s disease also shared risk SNPs with age-related phenotypes such as age-related macular degeneration and longevity. Smoking-related SNPs were linked to lung cancer and respiratory function. Alcohol-related SNPs were associated with cardiovascular and digestive system phenotypes and disorders. Two separate studies also identified a shared risk SNP for bipolar disorder and educational attainment. This review revealed a list of reproducible SNPs worthy of future functional investigation. Additionally, by identifying SNPs associated with multiple phenotypes, we illustrated the importance of studying the relationships among phenotypes to resolve the nature of their causal links. The insights within this review will hopefully pave the way for future evidence-based genetic studies. 2018-06-25 2019-03 /pmc/articles/PMC6372350/ /pubmed/29942042 http://dx.doi.org/10.1038/s41380-018-0055-z Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Horwitz, Tanya
Lam, Katie
Chen, Yu
Xia, Yan
Liu, Chunyu
A Decade in Psychiatric GWAS Research
title A Decade in Psychiatric GWAS Research
title_full A Decade in Psychiatric GWAS Research
title_fullStr A Decade in Psychiatric GWAS Research
title_full_unstemmed A Decade in Psychiatric GWAS Research
title_short A Decade in Psychiatric GWAS Research
title_sort decade in psychiatric gwas research
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372350/
https://www.ncbi.nlm.nih.gov/pubmed/29942042
http://dx.doi.org/10.1038/s41380-018-0055-z
work_keys_str_mv AT horwitztanya adecadeinpsychiatricgwasresearch
AT lamkatie adecadeinpsychiatricgwasresearch
AT chenyu adecadeinpsychiatricgwasresearch
AT xiayan adecadeinpsychiatricgwasresearch
AT liuchunyu adecadeinpsychiatricgwasresearch
AT horwitztanya decadeinpsychiatricgwasresearch
AT lamkatie decadeinpsychiatricgwasresearch
AT chenyu decadeinpsychiatricgwasresearch
AT xiayan decadeinpsychiatricgwasresearch
AT liuchunyu decadeinpsychiatricgwasresearch