TROY interacts with RKIP to promote glioma development

TROY is a component of the Nogo receptor complex and plays the key role in neuronal survival, migration, and differentiation. Here, we show the up-regulation of TROY in human glioma tissues and cells. Inhibition of TROY expression slowed glioma development in vivo and in vitro. Raf kinase inhibitor...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Xiujie, Bao, Yinghui, Meng, Wei, Yang, Ping, An, Yi, Ma, Jie, Tang, Yujie, Liu, Zhigang, Lu, Yan, Zhou, Jianfeng, Zhang, Yong, Feng, Jifeng, Gao, Xiaofei, Su, Zhida, Pu, Yingyan, He, Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372479/
https://www.ncbi.nlm.nih.gov/pubmed/30337686
http://dx.doi.org/10.1038/s41388-018-0503-x
Descripción
Sumario:TROY is a component of the Nogo receptor complex and plays the key role in neuronal survival, migration, and differentiation. Here, we show the up-regulation of TROY in human glioma tissues and cells. Inhibition of TROY expression slowed glioma development in vivo and in vitro. Raf kinase inhibitor (RKIP) was found to interact with TROY. The physical interaction of TROY/RKIP was confirmed via co-immunoprecipitation (co-IP) assays. Furthermore, we found that the TROY/RKIP interaction was enhanced by fetal bovine serum (FBS) exposure, and TROY knockdown also led to down-regulation of NF-κB. Finally, disruption of the TROY/RKIP interaction using the TAT-TROY (234–371 aa) protein reduced the glioma development in xenografted mice. This suggests the TROY/RKIP interaction is a potential target for therapy of gliomas.

Ejemplares similares