CBAP modulates Akt-dependent TSC2 phosphorylation to promote Rheb-mTORC1 signaling and growth of T-cell acute lymphoblastic leukemia

High-frequency relapse remains a clinical hurdle for complete remission of T-cell acute lymphoblastic leukemia (T-ALL) patients, with heterogeneous dysregulated signaling profiles—including of Raf-MEK-ERK and Akt-mTORC1-S6K signaling pathways—recently being implicated in disease outcomes. Here we re...

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Detalles Bibliográficos
Autores principales: Chiang, Yun-Jung, Liao, Wei-Ting, Ho, Kun-Chin, Wang, Shih-Hao, Chen, Yu-Guang, Ho, Ching-Liang, Huang, Shiu-Feng, Shih, Lee-Yung, Yang-Yen, Hsin-Fang, Yen, Jeffrey Jong-Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372575/
https://www.ncbi.nlm.nih.gov/pubmed/30266989
http://dx.doi.org/10.1038/s41388-018-0507-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372575/
https://www.ncbi.nlm.nih.gov/pubmed/30266989
http://dx.doi.org/10.1038/s41388-018-0507-6

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