Structural basis for chemically-induced homodimerization of a single domain antibody

Chemically-induced dimerization (CID) systems are essential tools to interrogate and control biological systems. AcVHH is a single domain antibody homo-dimerizing upon caffeine binding. AcVHH has a strong potential for clinical applications through caffeine-mediated in vivo control of therapeutic ge...

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Autores principales: Lesne, Jean, Chang, Hung-Ju, De Visch, Angelique, Paloni, Matteo, Barthe, Philippe, Guichou, Jean-François, Mayonove, Pauline, Barducci, Alessandro, Labesse, Gilles, Bonnet, Jerome, Cohen-Gonsaud, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372657/
https://www.ncbi.nlm.nih.gov/pubmed/30755682
http://dx.doi.org/10.1038/s41598-019-38752-y
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author Lesne, Jean
Chang, Hung-Ju
De Visch, Angelique
Paloni, Matteo
Barthe, Philippe
Guichou, Jean-François
Mayonove, Pauline
Barducci, Alessandro
Labesse, Gilles
Bonnet, Jerome
Cohen-Gonsaud, Martin
author_facet Lesne, Jean
Chang, Hung-Ju
De Visch, Angelique
Paloni, Matteo
Barthe, Philippe
Guichou, Jean-François
Mayonove, Pauline
Barducci, Alessandro
Labesse, Gilles
Bonnet, Jerome
Cohen-Gonsaud, Martin
author_sort Lesne, Jean
collection PubMed
description Chemically-induced dimerization (CID) systems are essential tools to interrogate and control biological systems. AcVHH is a single domain antibody homo-dimerizing upon caffeine binding. AcVHH has a strong potential for clinical applications through caffeine-mediated in vivo control of therapeutic gene networks. Here we provide the structural basis for caffeine-induced homo-dimerization of acVHH.
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spelling pubmed-63726572019-02-19 Structural basis for chemically-induced homodimerization of a single domain antibody Lesne, Jean Chang, Hung-Ju De Visch, Angelique Paloni, Matteo Barthe, Philippe Guichou, Jean-François Mayonove, Pauline Barducci, Alessandro Labesse, Gilles Bonnet, Jerome Cohen-Gonsaud, Martin Sci Rep Article Chemically-induced dimerization (CID) systems are essential tools to interrogate and control biological systems. AcVHH is a single domain antibody homo-dimerizing upon caffeine binding. AcVHH has a strong potential for clinical applications through caffeine-mediated in vivo control of therapeutic gene networks. Here we provide the structural basis for caffeine-induced homo-dimerization of acVHH. Nature Publishing Group UK 2019-02-12 /pmc/articles/PMC6372657/ /pubmed/30755682 http://dx.doi.org/10.1038/s41598-019-38752-y Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Lesne, Jean
Chang, Hung-Ju
De Visch, Angelique
Paloni, Matteo
Barthe, Philippe
Guichou, Jean-François
Mayonove, Pauline
Barducci, Alessandro
Labesse, Gilles
Bonnet, Jerome
Cohen-Gonsaud, Martin
Structural basis for chemically-induced homodimerization of a single domain antibody
title Structural basis for chemically-induced homodimerization of a single domain antibody
title_full Structural basis for chemically-induced homodimerization of a single domain antibody
title_fullStr Structural basis for chemically-induced homodimerization of a single domain antibody
title_full_unstemmed Structural basis for chemically-induced homodimerization of a single domain antibody
title_short Structural basis for chemically-induced homodimerization of a single domain antibody
title_sort structural basis for chemically-induced homodimerization of a single domain antibody
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372657/
https://www.ncbi.nlm.nih.gov/pubmed/30755682
http://dx.doi.org/10.1038/s41598-019-38752-y
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