Structural basis for chemically-induced homodimerization of a single domain antibody

Chemically-induced dimerization (CID) systems are essential tools to interrogate and control biological systems. AcVHH is a single domain antibody homo-dimerizing upon caffeine binding. AcVHH has a strong potential for clinical applications through caffeine-mediated in vivo control of therapeutic ge...

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Detalles Bibliográficos
Autores principales: Lesne, Jean, Chang, Hung-Ju, De Visch, Angelique, Paloni, Matteo, Barthe, Philippe, Guichou, Jean-François, Mayonove, Pauline, Barducci, Alessandro, Labesse, Gilles, Bonnet, Jerome, Cohen-Gonsaud, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372657/
https://www.ncbi.nlm.nih.gov/pubmed/30755682
http://dx.doi.org/10.1038/s41598-019-38752-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372657/
https://www.ncbi.nlm.nih.gov/pubmed/30755682
http://dx.doi.org/10.1038/s41598-019-38752-y

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