Cargando…

Exposure to Nanoscale Particulate Matter from Gestation to Adulthood Impairs Metabolic Homeostasis in Mice

Emerging evidence from epidemiological and animal studies suggests that exposure to traffic-related air pollutants and particulate matter less than 2.5 µm in diameter (PM(2.5)) contributes to development of obesity and related metabolic abnormalities. However, it is not known whether nanoscale parti...

Descripción completa

Detalles Bibliográficos
Autores principales: Woodward, Nicholas C., Crow, Amanda L., Zhang, Yang, Epstein, Sam, Hartiala, Jaana, Johnson, Richard, Kocalis, Heidi, Saffari, Arian, Sankaranarayanan, Ishwarya, Akbari, Omid, Ramanathan, Gajalakshmi, Araujo, Jesus A., Finch, Caleb E., Bouret, Sebastien G., Sioutas, Constantinos, Morgan, Todd E., Allayee, Hooman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372675/
https://www.ncbi.nlm.nih.gov/pubmed/30755631
http://dx.doi.org/10.1038/s41598-018-37704-2
_version_ 1783394799451111424
author Woodward, Nicholas C.
Crow, Amanda L.
Zhang, Yang
Epstein, Sam
Hartiala, Jaana
Johnson, Richard
Kocalis, Heidi
Saffari, Arian
Sankaranarayanan, Ishwarya
Akbari, Omid
Ramanathan, Gajalakshmi
Araujo, Jesus A.
Finch, Caleb E.
Bouret, Sebastien G.
Sioutas, Constantinos
Morgan, Todd E.
Allayee, Hooman
author_facet Woodward, Nicholas C.
Crow, Amanda L.
Zhang, Yang
Epstein, Sam
Hartiala, Jaana
Johnson, Richard
Kocalis, Heidi
Saffari, Arian
Sankaranarayanan, Ishwarya
Akbari, Omid
Ramanathan, Gajalakshmi
Araujo, Jesus A.
Finch, Caleb E.
Bouret, Sebastien G.
Sioutas, Constantinos
Morgan, Todd E.
Allayee, Hooman
author_sort Woodward, Nicholas C.
collection PubMed
description Emerging evidence from epidemiological and animal studies suggests that exposure to traffic-related air pollutants and particulate matter less than 2.5 µm in diameter (PM(2.5)) contributes to development of obesity and related metabolic abnormalities. However, it is not known whether nanoscale particulate matter (nPM) with aerodynamic diameter ≤200 nm have similar adverse metabolic effects. The goal of the present study was to determine the effects of prenatal and early life exposure to nPM on metabolic homeostasis in mice. C57BL/6 J mice were exposed to nPM or filtered air from gestation until 17 weeks of age and characterized for metabolic and behavioral parameters. In male mice, nPM exposure increased food intake, body weight, fat mass, adiposity, and whole-body glucose intolerance (p < 0.05). Consistent with these effects, male mice exposed to nPM displayed alterations in the expression of metabolically-relevant neuropeptides in the hypothalamus and decreased expression of insulin receptor signaling genes in adipose (p < 0.05). There were no differences in exploratory behavior or motor function, fasting lipid levels, or the inflammatory profile of adipose tissue. Our results provide evidence that chronic nPM exposure from gestation to early adulthood in male mice promotes metabolic dysregulation in part through modulation of feeding behavior and in the absence of an obesogenic diet.
format Online
Article
Text
id pubmed-6372675
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-63726752019-02-19 Exposure to Nanoscale Particulate Matter from Gestation to Adulthood Impairs Metabolic Homeostasis in Mice Woodward, Nicholas C. Crow, Amanda L. Zhang, Yang Epstein, Sam Hartiala, Jaana Johnson, Richard Kocalis, Heidi Saffari, Arian Sankaranarayanan, Ishwarya Akbari, Omid Ramanathan, Gajalakshmi Araujo, Jesus A. Finch, Caleb E. Bouret, Sebastien G. Sioutas, Constantinos Morgan, Todd E. Allayee, Hooman Sci Rep Article Emerging evidence from epidemiological and animal studies suggests that exposure to traffic-related air pollutants and particulate matter less than 2.5 µm in diameter (PM(2.5)) contributes to development of obesity and related metabolic abnormalities. However, it is not known whether nanoscale particulate matter (nPM) with aerodynamic diameter ≤200 nm have similar adverse metabolic effects. The goal of the present study was to determine the effects of prenatal and early life exposure to nPM on metabolic homeostasis in mice. C57BL/6 J mice were exposed to nPM or filtered air from gestation until 17 weeks of age and characterized for metabolic and behavioral parameters. In male mice, nPM exposure increased food intake, body weight, fat mass, adiposity, and whole-body glucose intolerance (p < 0.05). Consistent with these effects, male mice exposed to nPM displayed alterations in the expression of metabolically-relevant neuropeptides in the hypothalamus and decreased expression of insulin receptor signaling genes in adipose (p < 0.05). There were no differences in exploratory behavior or motor function, fasting lipid levels, or the inflammatory profile of adipose tissue. Our results provide evidence that chronic nPM exposure from gestation to early adulthood in male mice promotes metabolic dysregulation in part through modulation of feeding behavior and in the absence of an obesogenic diet. Nature Publishing Group UK 2019-02-12 /pmc/articles/PMC6372675/ /pubmed/30755631 http://dx.doi.org/10.1038/s41598-018-37704-2 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Woodward, Nicholas C.
Crow, Amanda L.
Zhang, Yang
Epstein, Sam
Hartiala, Jaana
Johnson, Richard
Kocalis, Heidi
Saffari, Arian
Sankaranarayanan, Ishwarya
Akbari, Omid
Ramanathan, Gajalakshmi
Araujo, Jesus A.
Finch, Caleb E.
Bouret, Sebastien G.
Sioutas, Constantinos
Morgan, Todd E.
Allayee, Hooman
Exposure to Nanoscale Particulate Matter from Gestation to Adulthood Impairs Metabolic Homeostasis in Mice
title Exposure to Nanoscale Particulate Matter from Gestation to Adulthood Impairs Metabolic Homeostasis in Mice
title_full Exposure to Nanoscale Particulate Matter from Gestation to Adulthood Impairs Metabolic Homeostasis in Mice
title_fullStr Exposure to Nanoscale Particulate Matter from Gestation to Adulthood Impairs Metabolic Homeostasis in Mice
title_full_unstemmed Exposure to Nanoscale Particulate Matter from Gestation to Adulthood Impairs Metabolic Homeostasis in Mice
title_short Exposure to Nanoscale Particulate Matter from Gestation to Adulthood Impairs Metabolic Homeostasis in Mice
title_sort exposure to nanoscale particulate matter from gestation to adulthood impairs metabolic homeostasis in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372675/
https://www.ncbi.nlm.nih.gov/pubmed/30755631
http://dx.doi.org/10.1038/s41598-018-37704-2
work_keys_str_mv AT woodwardnicholasc exposuretonanoscaleparticulatematterfromgestationtoadulthoodimpairsmetabolichomeostasisinmice
AT crowamandal exposuretonanoscaleparticulatematterfromgestationtoadulthoodimpairsmetabolichomeostasisinmice
AT zhangyang exposuretonanoscaleparticulatematterfromgestationtoadulthoodimpairsmetabolichomeostasisinmice
AT epsteinsam exposuretonanoscaleparticulatematterfromgestationtoadulthoodimpairsmetabolichomeostasisinmice
AT hartialajaana exposuretonanoscaleparticulatematterfromgestationtoadulthoodimpairsmetabolichomeostasisinmice
AT johnsonrichard exposuretonanoscaleparticulatematterfromgestationtoadulthoodimpairsmetabolichomeostasisinmice
AT kocalisheidi exposuretonanoscaleparticulatematterfromgestationtoadulthoodimpairsmetabolichomeostasisinmice
AT saffariarian exposuretonanoscaleparticulatematterfromgestationtoadulthoodimpairsmetabolichomeostasisinmice
AT sankaranarayananishwarya exposuretonanoscaleparticulatematterfromgestationtoadulthoodimpairsmetabolichomeostasisinmice
AT akbariomid exposuretonanoscaleparticulatematterfromgestationtoadulthoodimpairsmetabolichomeostasisinmice
AT ramanathangajalakshmi exposuretonanoscaleparticulatematterfromgestationtoadulthoodimpairsmetabolichomeostasisinmice
AT araujojesusa exposuretonanoscaleparticulatematterfromgestationtoadulthoodimpairsmetabolichomeostasisinmice
AT finchcalebe exposuretonanoscaleparticulatematterfromgestationtoadulthoodimpairsmetabolichomeostasisinmice
AT bouretsebastieng exposuretonanoscaleparticulatematterfromgestationtoadulthoodimpairsmetabolichomeostasisinmice
AT sioutasconstantinos exposuretonanoscaleparticulatematterfromgestationtoadulthoodimpairsmetabolichomeostasisinmice
AT morgantodde exposuretonanoscaleparticulatematterfromgestationtoadulthoodimpairsmetabolichomeostasisinmice
AT allayeehooman exposuretonanoscaleparticulatematterfromgestationtoadulthoodimpairsmetabolichomeostasisinmice