Epithelial Cells and Fibroblasts from the Human Female Reproductive Tract Accumulate and Release TFV and TAF to Sustain Inhibition of HIV Infection of CD4+ T cells

Tenofovir (TFV) treatment of female reproductive tract (FRT) cells results in differential accumulation of intracellular Tenofovir diphosphate (TFV-DP) in different cell types, with greater concentrations in epithelial cells (100-fold) and fibroblasts (10-fold) than in CD4+ T cells. The possibility...

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Detalles Bibliográficos
Autores principales: Shen, Zheng, Rodriguez-Garcia, Marta, Patel, Mickey V., Bodwell, Jack, Wira, Charles R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372694/
https://www.ncbi.nlm.nih.gov/pubmed/30755713
http://dx.doi.org/10.1038/s41598-018-38205-y

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