Deregulated Gab2 phosphorylation mediates aberrant AKT and STAT3 signaling upon PIK3R1 loss in ovarian cancer

Copy number loss of PIK3R1 (p85α) most commonly occurs in ovarian cancer among all cancer types. Here we report that ovarian cancer cells manifest a spectrum of tumorigenic phenotypes upon knockdown of PIK3R1. PIK3R1 loss activates AKT and p110-independent JAK2/STAT3 signaling through inducing chang...

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Detalles Bibliográficos
Autores principales: Li, Xinran, Mak, Victor C. Y., Zhou, Yuan, Wang, Chao, Wong, Esther S. Y., Sharma, Rakesh, Lu, Yiling, Cheung, Annie N. Y., Mills, Gordon B., Cheung, Lydia W. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372715/
https://www.ncbi.nlm.nih.gov/pubmed/30755611
http://dx.doi.org/10.1038/s41467-019-08574-7

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