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Differential PI(4,5)P(2) sensitivities of TRPC4, C5 homomeric and TRPC1/4, C1/5 heteromeric channels

Transient receptor potential canonical (TRPC) 4 and TRPC5 channels are modulated by the Gα(q)-PLC pathway. Since phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) maintains TRPC4 and TRPC5 channel function, the Gα(q)-PLC pathway inhibits channel activity by depleting PI(4,5)P(2). Here we investiga...

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Detalles Bibliográficos
Autores principales:	Ko, Juyeon, Myeong, Jongyun, Shin, Young-Cheul, So, Insuk
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372716/ https://www.ncbi.nlm.nih.gov/pubmed/30755645 http://dx.doi.org/10.1038/s41598-018-38443-0

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