Autophagic flux blockage in alveolar epithelial cells is essential in silica nanoparticle-induced pulmonary fibrosis

Silica nanoparticles (SiNPs) have been reported to induce pulmonary fibrosis (PF) with an unknown mechanism. Recently, the activation of autophagy, a lysosome-dependent cell degradation pathway, by SiNPs has been identified in alveolar epithelial cells (AECs). However, the underlying mechanism and t...

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Detalles Bibliográficos
Autores principales: Zhao, Xinyuan, Wei, Saisai, Li, Zhijian, Lin, Chen, Zhu, Zhenfeng, Sun, Desen, Bai, Rongpan, Qian, Jun, Gao, Xiangwei, Chen, Guangdi, Xu, Zhengping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372720/
https://www.ncbi.nlm.nih.gov/pubmed/30755584
http://dx.doi.org/10.1038/s41419-019-1340-8

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