Serotonin reuptake inhibitors and bone health: A review of clinical studies and plausible mechanisms

Selective serotonin reuptake inhibitors (SSRIs) are currently the treatment of choice in depression and constitute major portion of prescription in depressive patients. The role of serotonin receptors in bone is emerging, raising certain questions regarding the effect of blockade of serotonin reupta...

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Autores principales: Wadhwa, Ravisha, Kumar, Manoj, Talegaonkar, Sushama, Vohora, Divya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Osteoporosis 2017
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372777/
https://www.ncbi.nlm.nih.gov/pubmed/30775508
http://dx.doi.org/10.1016/j.afos.2017.05.002
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author Wadhwa, Ravisha
Kumar, Manoj
Talegaonkar, Sushama
Vohora, Divya
author_facet Wadhwa, Ravisha
Kumar, Manoj
Talegaonkar, Sushama
Vohora, Divya
author_sort Wadhwa, Ravisha
collection PubMed
description Selective serotonin reuptake inhibitors (SSRIs) are currently the treatment of choice in depression and constitute major portion of prescription in depressive patients. The role of serotonin receptors in bone is emerging, raising certain questions regarding the effect of blockade of serotonin reuptake in the bone metabolism. Clinical studies have reported an association of SSRI antidepressants which with increase in fracture and decrease in bone mineral density. This review focus on recent evidence that evaluate the association of SSRIs with the risk of fracture and bone mineral density and also the probable mechanisms that might be involved in such effects.
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spelling pubmed-63727772019-02-15 Serotonin reuptake inhibitors and bone health: A review of clinical studies and plausible mechanisms Wadhwa, Ravisha Kumar, Manoj Talegaonkar, Sushama Vohora, Divya Osteoporos Sarcopenia Review Article Selective serotonin reuptake inhibitors (SSRIs) are currently the treatment of choice in depression and constitute major portion of prescription in depressive patients. The role of serotonin receptors in bone is emerging, raising certain questions regarding the effect of blockade of serotonin reuptake in the bone metabolism. Clinical studies have reported an association of SSRI antidepressants which with increase in fracture and decrease in bone mineral density. This review focus on recent evidence that evaluate the association of SSRIs with the risk of fracture and bone mineral density and also the probable mechanisms that might be involved in such effects. Korean Society of Osteoporosis 2017-06 2017-06-09 /pmc/articles/PMC6372777/ /pubmed/30775508 http://dx.doi.org/10.1016/j.afos.2017.05.002 Text en © 2017 The Korean Society of Osteoporosis. Publishing services by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Wadhwa, Ravisha
Kumar, Manoj
Talegaonkar, Sushama
Vohora, Divya
Serotonin reuptake inhibitors and bone health: A review of clinical studies and plausible mechanisms
title Serotonin reuptake inhibitors and bone health: A review of clinical studies and plausible mechanisms
title_full Serotonin reuptake inhibitors and bone health: A review of clinical studies and plausible mechanisms
title_fullStr Serotonin reuptake inhibitors and bone health: A review of clinical studies and plausible mechanisms
title_full_unstemmed Serotonin reuptake inhibitors and bone health: A review of clinical studies and plausible mechanisms
title_short Serotonin reuptake inhibitors and bone health: A review of clinical studies and plausible mechanisms
title_sort serotonin reuptake inhibitors and bone health: a review of clinical studies and plausible mechanisms
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372777/
https://www.ncbi.nlm.nih.gov/pubmed/30775508
http://dx.doi.org/10.1016/j.afos.2017.05.002
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