Repression of Human Papillomavirus Oncogene Expression under Hypoxia Is Mediated by PI3K/mTORC2/AKT Signaling

Hypoxia is linked to therapeutic resistance and poor clinical prognosis for many tumor entities, including human papillomavirus (HPV)-positive cancers. Notably, HPV-positive cancer cells can induce a dormant state under hypoxia, characterized by a reversible growth arrest and strong repression of vi...

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Detalles Bibliográficos
Autores principales: Bossler, Felicitas, Kuhn, Bianca J., Günther, Thomas, Kraemer, Stephen J., Khalkar, Prajakta, Adrian, Svenja, Lohrey, Claudia, Holzer, Angela, Shimobayashi, Mitsugu, Dürst, Matthias, Mayer, Arnulf, Rösl, Frank, Grundhoff, Adam, Krijgsveld, Jeroen, Hoppe-Seyler, Karin, Hoppe-Seyler, Felix
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372795/
https://www.ncbi.nlm.nih.gov/pubmed/30755508
http://dx.doi.org/10.1128/mBio.02323-18

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