X-Chromosome Dosage Modulates Multiple Molecular and Cellular Properties of Mouse Pluripotent Stem Cells Independently of Global DNA Methylation Levels

Reprogramming female mouse somatic cells into induced pluripotent stem cells (iPSCs) leads to X-chromosome reactivation. The extent to which increased X-chromosome dosage (X-dosage) in female iPSCs compared with male iPSCs leads to differences in the properties of iPSCs is still unclear. We show tha...

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Detalles Bibliográficos
Autores principales: Song, Juan, Janiszewski, Adrian, De Geest, Natalie, Vanheer, Lotte, Talon, Irene, El Bakkali, Mouna, Oh, Taeho, Pasque, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372905/
https://www.ncbi.nlm.nih.gov/pubmed/30639215
http://dx.doi.org/10.1016/j.stemcr.2018.12.004

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