Connexin Hemichannels in Astrocytes: Role in CNS Disorders

In the central nervous system (CNS), astrocytes form networks interconnected by gap junctions made from connexins of the subtypes Cx30 and Cx43. When unopposed by an adjoining hemichannel, astrocytic connexins can act as hemichannels to control the release of small molecules such as ATP and glutamat...

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Autores principales: Xing, LingYan, Yang, Tuo, Cui, ShuSen, Chen, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372977/
https://www.ncbi.nlm.nih.gov/pubmed/30787868
http://dx.doi.org/10.3389/fnmol.2019.00023
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author Xing, LingYan
Yang, Tuo
Cui, ShuSen
Chen, Gang
author_facet Xing, LingYan
Yang, Tuo
Cui, ShuSen
Chen, Gang
author_sort Xing, LingYan
collection PubMed
description In the central nervous system (CNS), astrocytes form networks interconnected by gap junctions made from connexins of the subtypes Cx30 and Cx43. When unopposed by an adjoining hemichannel, astrocytic connexins can act as hemichannels to control the release of small molecules such as ATP and glutamate into the extracellular space. Accruing evidence indicates that astrocytic connexins are crucial for the coordination and maintenance of physiologic CNS activity. Here we provide an update on the role of astrocytic connexins in neurodegenerative disorders, glioma, and ischemia. In addition, we address the regulation of Cx43 in chronic pain.
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spelling pubmed-63729772019-02-20 Connexin Hemichannels in Astrocytes: Role in CNS Disorders Xing, LingYan Yang, Tuo Cui, ShuSen Chen, Gang Front Mol Neurosci Neuroscience In the central nervous system (CNS), astrocytes form networks interconnected by gap junctions made from connexins of the subtypes Cx30 and Cx43. When unopposed by an adjoining hemichannel, astrocytic connexins can act as hemichannels to control the release of small molecules such as ATP and glutamate into the extracellular space. Accruing evidence indicates that astrocytic connexins are crucial for the coordination and maintenance of physiologic CNS activity. Here we provide an update on the role of astrocytic connexins in neurodegenerative disorders, glioma, and ischemia. In addition, we address the regulation of Cx43 in chronic pain. Frontiers Media S.A. 2019-02-06 /pmc/articles/PMC6372977/ /pubmed/30787868 http://dx.doi.org/10.3389/fnmol.2019.00023 Text en Copyright © 2019 Xing, Yang, Cui and Chen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Xing, LingYan
Yang, Tuo
Cui, ShuSen
Chen, Gang
Connexin Hemichannels in Astrocytes: Role in CNS Disorders
title Connexin Hemichannels in Astrocytes: Role in CNS Disorders
title_full Connexin Hemichannels in Astrocytes: Role in CNS Disorders
title_fullStr Connexin Hemichannels in Astrocytes: Role in CNS Disorders
title_full_unstemmed Connexin Hemichannels in Astrocytes: Role in CNS Disorders
title_short Connexin Hemichannels in Astrocytes: Role in CNS Disorders
title_sort connexin hemichannels in astrocytes: role in cns disorders
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372977/
https://www.ncbi.nlm.nih.gov/pubmed/30787868
http://dx.doi.org/10.3389/fnmol.2019.00023
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