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A fragment activity assay reveals the key residues of TBC1D15 GTPase-activating protein (GAP) in Chiloscyllium plagiosum

BACKGROUND: GTPase-activating proteins (GAPs) with a TBC (Tre-2/Bub2/Cdc16) domain architecture serve as negative regulators of Rab GTPases. The related crystal structure has been studied and reported by other members of our research group in 2017 (Chen et al. in Protein Sci 26(4):834–846, 2017). Th...

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Detalles Bibliográficos
Autores principales:	Jin, Yangyang, Lin, Guodong, Chen, Yanna, Ge, Yinghua, Liang, Ruofeng, Wu, Jia, Chen, Jianqing, Wang, Dan, Shi, Hengbo, Fei, Hui, Lv, Zhengbing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373008/ https://www.ncbi.nlm.nih.gov/pubmed/30755162 http://dx.doi.org/10.1186/s12867-019-0122-2

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