Autophagy inhibition potentiates the anti-angiogenic property of multikinase inhibitor anlotinib through JAK2/STAT3/VEGFA signaling in non-small cell lung cancer cells

BACKGROUND: The efficacy and safety of multikinase inhibitor anlotinib have been confirmed in the treatment of advanced non-small cell lung cancer (NSCLC). However, the direct functional mechanisms of tumor lethality mediated by anlotinib were not fully elucidated, and the underlying mechanisms rela...

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Detalles Bibliográficos
Autores principales: Liang, Lijun, Hui, Kaiyuan, Hu, Chenxi, Wen, Yixuan, Yang, Shikun, Zhu, Panrong, Wang, Lei, Xia, Youyou, Qiao, Yun, Sun, Wen, Fei, Jiayan, Chen, Ting, Zhao, Fenghua, Yang, Baocheng, Jiang, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373028/
https://www.ncbi.nlm.nih.gov/pubmed/30755242
http://dx.doi.org/10.1186/s13046-019-1093-3

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