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Nociceptin/orphanin FQ modulates energy homeostasis through inhibition of neurotransmission at VMN SF-1/ARC POMC synapses in a sex- and diet-dependent manner

BACKGROUND: Orphanin FQ (aka nociceptin; N/OFQ) binds to its nociceptin opioid peptide (NOP) receptor expressed in proopiomelanocortin (POMC) neurons within the arcuate nucleus (ARC), a critical anorexigenic component of the hypothalamic energy balance circuitry. It inhibits POMC neurons by modifyin...

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Detalles Bibliográficos
Autores principales:	Hernandez, Jennifer, Fabelo, Carolina, Perez, Lynnea, Moore, Clare, Chang, Rachel, Wagner, Edward J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373052/ https://www.ncbi.nlm.nih.gov/pubmed/30755252 http://dx.doi.org/10.1186/s13293-019-0220-3

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