PRIMA-1(MET)-induced neuroblastoma cell death is modulated by p53 and mycn through glutathione level

BACKGROUND: Neuroblastoma is the most common extracranial solid tumor in children. This cancer has a low frequency of TP53 mutations and its downstream pathway is usually intact. This study assessed the efficacy of the p53 activator, PRIMA-1(MET), in inducing neuroblastoma cell death. METHODS: CellT...

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Detalles Bibliográficos
Autores principales: Mlakar, Vid, Jurkovic Mlakar, Simona, Lesne, Laurence, Marino, Denis, Rathi, Komal S., Maris, John M., Ansari, Marc, Gumy-Pause, Fabienne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373164/
https://www.ncbi.nlm.nih.gov/pubmed/30755224
http://dx.doi.org/10.1186/s13046-019-1066-6

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