Mesencephalic astrocyte-derived neurotrophic factor (MANF) protects against Aβ toxicity via attenuating Aβ-induced endoplasmic reticulum stress

BACKGROUND: Extracellular accumulation of amyloid β-peptide (Aβ) is one of pathological hallmarks of Alzheimer’s disease (AD) and contributes to the neuronal loss. Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum (ER) stress-inducible neurotrophic factor. Many g...

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Detalles Bibliográficos
Autores principales: Xu, Shengchun, Di, Zemin, He, Yufeng, Wang, Runjie, Ma, Yuyang, Sun, Rui, Li, Jing, Wang, Tao, Shen, Yujun, Fang, Shengyun, Feng, Lijie, Shen, Yuxian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373169/
https://www.ncbi.nlm.nih.gov/pubmed/30760285
http://dx.doi.org/10.1186/s12974-019-1429-0

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