Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury

The transcription factor NRF2, governed by its repressor KEAP1, protects cells against oxidative stress. There is interest in modelling the NRF2 response to improve the prediction of clinical toxicities such as drug-induced liver injury (DILI). However, very little is known about the makeup of the N...

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Detalles Bibliográficos
Autores principales: Copple, Ian M., den Hollander, Wouter, Callegaro, Giulia, Mutter, Fiona E., Maggs, James L., Schofield, Amy L., Rainbow, Lucille, Fang, Yongxiang, Sutherland, Jeffrey J., Ellis, Ewa C., Ingelman-Sundberg, Magnus, Fenwick, Stephen W., Goldring, Christopher E., van de Water, Bob, Stevens, James L., Park, B. Kevin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
In Vitro Systems
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373176/
https://www.ncbi.nlm.nih.gov/pubmed/30426165
http://dx.doi.org/10.1007/s00204-018-2354-1

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