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Relation of the degree of obesity in childhood to adipose tissue insulin resistance

AIMS: In this study, we investigated whether adipose tissue insulin resistance (IR) is affected by the degree of obesity during the fasting and post-prandial state, independent of glucose tolerance among obese children and adolescents. We also tested whether systemic subclinical inflammation is asso...

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Autores principales: Hagman, Emilia, Besor, Omri, Hershkop, Karen, Santoro, Nicola, Pierpont, Bridget, Mata, Mariana, Caprio, Sonia, Weiss, Ram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Milan 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373259/
https://www.ncbi.nlm.nih.gov/pubmed/30637483
http://dx.doi.org/10.1007/s00592-018-01285-3
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author Hagman, Emilia
Besor, Omri
Hershkop, Karen
Santoro, Nicola
Pierpont, Bridget
Mata, Mariana
Caprio, Sonia
Weiss, Ram
author_facet Hagman, Emilia
Besor, Omri
Hershkop, Karen
Santoro, Nicola
Pierpont, Bridget
Mata, Mariana
Caprio, Sonia
Weiss, Ram
author_sort Hagman, Emilia
collection PubMed
description AIMS: In this study, we investigated whether adipose tissue insulin resistance (IR) is affected by the degree of obesity during the fasting and post-prandial state, independent of glucose tolerance among obese children and adolescents. We also tested whether systemic subclinical inflammation is associated with adipose tissue IR. METHODS: Subjects were recruited to the Yale Pathophysiology of Type 2 Diabetes in Youth Study (NCT01967849). An oral glucose-tolerance test was performed to establish glucose-tolerance status and blood samples were drawn for measurement of free fatty acids (FFAs), to calculate the area under the curve (AUC) of FFA. Adipose tissue insulin resistance was calculated as the product of insulin and FFA concentrations. RESULTS: In total, 671 children and adolescents (58.6% females) were included with a mean age of 13.3(2.7) years and BMI Z score of 2.45(0.31). The degree of obesity emerged as an independent predictor of both fasting and post-prandial adipose IR, p < 0.0001. Higher degree of obesity was associated with greater AUC FFA (lower suppression) compared to lower degree of obesity, p = 0.01. Furthermore, higher levels of IL-6 were positively associated with post-prandial adipose tissue IR, p = 0.02. CONCLUSIONS: The degree of obesity in childhood and adolescence is strongly associated with adipose tissue IR independent of glucose tolerance. This is reflected not only in calculated indices of adipose IR but also in lower suppression of FFAs during the OGTT regardless of glucose tolerance or fasting adipose tissue IR. Furthermore, markers of subclinical inflammation such as IL-6 are associated with adipose tissue IR, independent of other factors. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00592-018-01285-3) contains supplementary material, which is available to authorized users.
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spelling pubmed-63732592019-03-01 Relation of the degree of obesity in childhood to adipose tissue insulin resistance Hagman, Emilia Besor, Omri Hershkop, Karen Santoro, Nicola Pierpont, Bridget Mata, Mariana Caprio, Sonia Weiss, Ram Acta Diabetol Original Article AIMS: In this study, we investigated whether adipose tissue insulin resistance (IR) is affected by the degree of obesity during the fasting and post-prandial state, independent of glucose tolerance among obese children and adolescents. We also tested whether systemic subclinical inflammation is associated with adipose tissue IR. METHODS: Subjects were recruited to the Yale Pathophysiology of Type 2 Diabetes in Youth Study (NCT01967849). An oral glucose-tolerance test was performed to establish glucose-tolerance status and blood samples were drawn for measurement of free fatty acids (FFAs), to calculate the area under the curve (AUC) of FFA. Adipose tissue insulin resistance was calculated as the product of insulin and FFA concentrations. RESULTS: In total, 671 children and adolescents (58.6% females) were included with a mean age of 13.3(2.7) years and BMI Z score of 2.45(0.31). The degree of obesity emerged as an independent predictor of both fasting and post-prandial adipose IR, p < 0.0001. Higher degree of obesity was associated with greater AUC FFA (lower suppression) compared to lower degree of obesity, p = 0.01. Furthermore, higher levels of IL-6 were positively associated with post-prandial adipose tissue IR, p = 0.02. CONCLUSIONS: The degree of obesity in childhood and adolescence is strongly associated with adipose tissue IR independent of glucose tolerance. This is reflected not only in calculated indices of adipose IR but also in lower suppression of FFAs during the OGTT regardless of glucose tolerance or fasting adipose tissue IR. Furthermore, markers of subclinical inflammation such as IL-6 are associated with adipose tissue IR, independent of other factors. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00592-018-01285-3) contains supplementary material, which is available to authorized users. Springer Milan 2019-01-12 2019 /pmc/articles/PMC6373259/ /pubmed/30637483 http://dx.doi.org/10.1007/s00592-018-01285-3 Text en © The Author(s) 2019 OpenAccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Hagman, Emilia
Besor, Omri
Hershkop, Karen
Santoro, Nicola
Pierpont, Bridget
Mata, Mariana
Caprio, Sonia
Weiss, Ram
Relation of the degree of obesity in childhood to adipose tissue insulin resistance
title Relation of the degree of obesity in childhood to adipose tissue insulin resistance
title_full Relation of the degree of obesity in childhood to adipose tissue insulin resistance
title_fullStr Relation of the degree of obesity in childhood to adipose tissue insulin resistance
title_full_unstemmed Relation of the degree of obesity in childhood to adipose tissue insulin resistance
title_short Relation of the degree of obesity in childhood to adipose tissue insulin resistance
title_sort relation of the degree of obesity in childhood to adipose tissue insulin resistance
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373259/
https://www.ncbi.nlm.nih.gov/pubmed/30637483
http://dx.doi.org/10.1007/s00592-018-01285-3
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