Lanadelumab for the Prophylactic Treatment of Hereditary Angioedema with C1 Inhibitor Deficiency: A Review of Preclinical and Phase I Studies

Hereditary angioedema (HAE) with C1 esterase inhibitor (C1-INH) deficiency (C1-INH-HAE) is a rare disease characterized by diminished levels or dysfunctional activity of C1-INH, leading to dysregulated plasma kallikrein activity within the kallikrein–kinin pathway. Symptoms manifest as painful, pote...

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Detalles Bibliográficos
Autores principales: Busse, Paula J., Farkas, Henriette, Banerji, Aleena, Lumry, William R., Longhurst, Hilary J., Sexton, Daniel J., Riedl, Marc A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373397/
https://www.ncbi.nlm.nih.gov/pubmed/30539362
http://dx.doi.org/10.1007/s40259-018-0325-y

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