The CXCL8-CXCR1/2 Axis as a Therapeutic Target in Breast Cancer Stem-Like Cells

Cancer stem-like cells (CSC) have been targeted by different strategies over the last decade. This mini review focuses on preclinical and clinical results obtained by interfering with chemokine receptors CXCR1 and CXCR2 in breast cancer. This strategy is currently being tested in a randomized, doubl...

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Detalles Bibliográficos
Autor principal: Ruffini, Pier Adelchi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373429/
https://www.ncbi.nlm.nih.gov/pubmed/30788286
http://dx.doi.org/10.3389/fonc.2019.00040
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author Ruffini, Pier Adelchi
author_facet Ruffini, Pier Adelchi
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description Cancer stem-like cells (CSC) have been targeted by different strategies over the last decade. This mini review focuses on preclinical and clinical results obtained by interfering with chemokine receptors CXCR1 and CXCR2 in breast cancer. This strategy is currently being tested in a randomized, double blind phase 2 clinical trial.
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spelling pubmed-63734292019-02-20 The CXCL8-CXCR1/2 Axis as a Therapeutic Target in Breast Cancer Stem-Like Cells Ruffini, Pier Adelchi Front Oncol Oncology Cancer stem-like cells (CSC) have been targeted by different strategies over the last decade. This mini review focuses on preclinical and clinical results obtained by interfering with chemokine receptors CXCR1 and CXCR2 in breast cancer. This strategy is currently being tested in a randomized, double blind phase 2 clinical trial. Frontiers Media S.A. 2019-02-06 /pmc/articles/PMC6373429/ /pubmed/30788286 http://dx.doi.org/10.3389/fonc.2019.00040 Text en Copyright © 2019 Ruffini. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Ruffini, Pier Adelchi
The CXCL8-CXCR1/2 Axis as a Therapeutic Target in Breast Cancer Stem-Like Cells
title The CXCL8-CXCR1/2 Axis as a Therapeutic Target in Breast Cancer Stem-Like Cells
title_full The CXCL8-CXCR1/2 Axis as a Therapeutic Target in Breast Cancer Stem-Like Cells
title_fullStr The CXCL8-CXCR1/2 Axis as a Therapeutic Target in Breast Cancer Stem-Like Cells
title_full_unstemmed The CXCL8-CXCR1/2 Axis as a Therapeutic Target in Breast Cancer Stem-Like Cells
title_short The CXCL8-CXCR1/2 Axis as a Therapeutic Target in Breast Cancer Stem-Like Cells
title_sort cxcl8-cxcr1/2 axis as a therapeutic target in breast cancer stem-like cells
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373429/
https://www.ncbi.nlm.nih.gov/pubmed/30788286
http://dx.doi.org/10.3389/fonc.2019.00040
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