Non-Cell-Autonomous Neurotoxicity in Parkinson’s Disease Mediated by Astroglial α-Synuclein

Non-cell-autonomous effects on neuronal cells are considered to be involved in the pathogenesis of neurodegenerative diseases but have yet to be mechanistically proven. In this issue of Stem Cell Reports, di Domenico et al. provide direct evidence that α-synuclein transferred from astrocytes exerts...

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Autores principales: Chai, MuhChyi, Kohyama, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373431/
https://www.ncbi.nlm.nih.gov/pubmed/30759377
http://dx.doi.org/10.1016/j.stemcr.2019.01.011
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author Chai, MuhChyi
Kohyama, Jun
author_facet Chai, MuhChyi
Kohyama, Jun
author_sort Chai, MuhChyi
collection PubMed
description Non-cell-autonomous effects on neuronal cells are considered to be involved in the pathogenesis of neurodegenerative diseases but have yet to be mechanistically proven. In this issue of Stem Cell Reports, di Domenico et al. provide direct evidence that α-synuclein transferred from astrocytes exerts non-cell-autonomous neuronal dysfunction on dopaminergic neurons in Parkinson’s disease (PD).
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spelling pubmed-63734312019-02-25 Non-Cell-Autonomous Neurotoxicity in Parkinson’s Disease Mediated by Astroglial α-Synuclein Chai, MuhChyi Kohyama, Jun Stem Cell Reports Preview Non-cell-autonomous effects on neuronal cells are considered to be involved in the pathogenesis of neurodegenerative diseases but have yet to be mechanistically proven. In this issue of Stem Cell Reports, di Domenico et al. provide direct evidence that α-synuclein transferred from astrocytes exerts non-cell-autonomous neuronal dysfunction on dopaminergic neurons in Parkinson’s disease (PD). Elsevier 2019-02-12 /pmc/articles/PMC6373431/ /pubmed/30759377 http://dx.doi.org/10.1016/j.stemcr.2019.01.011 Text en © 2019 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Preview
Chai, MuhChyi
Kohyama, Jun
Non-Cell-Autonomous Neurotoxicity in Parkinson’s Disease Mediated by Astroglial α-Synuclein
title Non-Cell-Autonomous Neurotoxicity in Parkinson’s Disease Mediated by Astroglial α-Synuclein
title_full Non-Cell-Autonomous Neurotoxicity in Parkinson’s Disease Mediated by Astroglial α-Synuclein
title_fullStr Non-Cell-Autonomous Neurotoxicity in Parkinson’s Disease Mediated by Astroglial α-Synuclein
title_full_unstemmed Non-Cell-Autonomous Neurotoxicity in Parkinson’s Disease Mediated by Astroglial α-Synuclein
title_short Non-Cell-Autonomous Neurotoxicity in Parkinson’s Disease Mediated by Astroglial α-Synuclein
title_sort non-cell-autonomous neurotoxicity in parkinson’s disease mediated by astroglial α-synuclein
topic Preview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373431/
https://www.ncbi.nlm.nih.gov/pubmed/30759377
http://dx.doi.org/10.1016/j.stemcr.2019.01.011
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AT kohyamajun noncellautonomousneurotoxicityinparkinsonsdiseasemediatedbyastroglialasynuclein

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