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Lack of UGT polymorphism association with idasanutlin pharmacokinetics in solid tumor patients

PURPOSE: Idasanutlin is a selective small-molecule MDM2 antagonist. It activates the tumor suppressor TP53 and is in phase 3 clinical trial for acute myeloid leukemia. Nonclinical studies have shown that glucuronidation is the major metabolizing mechanism for idasanutlin and UGT1A3 is the major meta...

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Detalles Bibliográficos
Autores principales:	So, W. Venus, Ou Yang, Tai-Hsien, Yang, Xing, Zhi, Jianguo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2018
Materias:	Short Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373577/ https://www.ncbi.nlm.nih.gov/pubmed/30511219 http://dx.doi.org/10.1007/s00280-018-3741-2

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