Identification of IQM-266, a Novel DREAM Ligand That Modulates K(V)4 Currents

Downstream Regulatory Element Antagonist Modulator (DREAM)/KChIP3/calsenilin is a neuronal calcium sensor (NCS) with multiple functions, including the regulation of A-type outward potassium currents (I(A)). This effect is mediated by the interaction between DREAM and K(V)4 potassium channels and it...

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Detalles Bibliográficos
Autores principales: Peraza, Diego A., Cercós, Pilar, Miaja, Pablo, Merinero, Yaiza G., Lagartera, Laura, Socuéllamos, Paula G., Izquierdo García, Carolina, Sánchez, Sara A., López-Hurtado, Alejandro, Martín-Martínez, Mercedes, Olivos-Oré, Luis A., Naranjo, José R., Artalejo, Antonio R., Gutiérrez-Rodríguez, Marta, Valenzuela, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373780/
https://www.ncbi.nlm.nih.gov/pubmed/30787866
http://dx.doi.org/10.3389/fnmol.2019.00011

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