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Spontaneous Tumor Lysis Syndrome as Presenting Sign of Metastatic Prostate Cancer

Spontaneous tumor lysis syndrome is an exceedingly rare manifestation of metastatic prostate cancer. It can masquerade as thrombotic thrombocytopenic purpura (TTP) or complement-mediated hemolytic uremic syndrome (HUS). These entities present with microangiopathic hemolytic anemia, thrombocytopenia,...

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Autores principales: McGhee-Jez, Amy, Batra, Vivek, Sunder, Tara, Rizk, Sanaa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373879/
https://www.ncbi.nlm.nih.gov/pubmed/30788195
http://dx.doi.org/10.7759/cureus.3706
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author McGhee-Jez, Amy
Batra, Vivek
Sunder, Tara
Rizk, Sanaa
author_facet McGhee-Jez, Amy
Batra, Vivek
Sunder, Tara
Rizk, Sanaa
author_sort McGhee-Jez, Amy
collection PubMed
description Spontaneous tumor lysis syndrome is an exceedingly rare manifestation of metastatic prostate cancer. It can masquerade as thrombotic thrombocytopenic purpura (TTP) or complement-mediated hemolytic uremic syndrome (HUS). These entities present with microangiopathic hemolytic anemia, thrombocytopenia, and renal failure, and improve with the initiation of plasma exchange and steroids. In situations where the laboratory data does not wholly validate the presumed diagnosis and clinical and laboratory deterioration occurs in spite of appropriate treatment, it is necessary to expand the differential diagnosis and investigation. In this case, worsening renal function, cytopenias, lactate dehydrogenase, and uric acid in the setting of proper treatment for TTP and complement-mediated HUS prompted additional analysis. This workup revealed bone marrow infiltration by metastatic prostate cancer complicated by tumor lysis syndrome.
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spelling pubmed-63738792019-02-20 Spontaneous Tumor Lysis Syndrome as Presenting Sign of Metastatic Prostate Cancer McGhee-Jez, Amy Batra, Vivek Sunder, Tara Rizk, Sanaa Cureus Oncology Spontaneous tumor lysis syndrome is an exceedingly rare manifestation of metastatic prostate cancer. It can masquerade as thrombotic thrombocytopenic purpura (TTP) or complement-mediated hemolytic uremic syndrome (HUS). These entities present with microangiopathic hemolytic anemia, thrombocytopenia, and renal failure, and improve with the initiation of plasma exchange and steroids. In situations where the laboratory data does not wholly validate the presumed diagnosis and clinical and laboratory deterioration occurs in spite of appropriate treatment, it is necessary to expand the differential diagnosis and investigation. In this case, worsening renal function, cytopenias, lactate dehydrogenase, and uric acid in the setting of proper treatment for TTP and complement-mediated HUS prompted additional analysis. This workup revealed bone marrow infiltration by metastatic prostate cancer complicated by tumor lysis syndrome. Cureus 2018-12-08 /pmc/articles/PMC6373879/ /pubmed/30788195 http://dx.doi.org/10.7759/cureus.3706 Text en Copyright © 2018, McGhee-Jez et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Oncology
McGhee-Jez, Amy
Batra, Vivek
Sunder, Tara
Rizk, Sanaa
Spontaneous Tumor Lysis Syndrome as Presenting Sign of Metastatic Prostate Cancer
title Spontaneous Tumor Lysis Syndrome as Presenting Sign of Metastatic Prostate Cancer
title_full Spontaneous Tumor Lysis Syndrome as Presenting Sign of Metastatic Prostate Cancer
title_fullStr Spontaneous Tumor Lysis Syndrome as Presenting Sign of Metastatic Prostate Cancer
title_full_unstemmed Spontaneous Tumor Lysis Syndrome as Presenting Sign of Metastatic Prostate Cancer
title_short Spontaneous Tumor Lysis Syndrome as Presenting Sign of Metastatic Prostate Cancer
title_sort spontaneous tumor lysis syndrome as presenting sign of metastatic prostate cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373879/
https://www.ncbi.nlm.nih.gov/pubmed/30788195
http://dx.doi.org/10.7759/cureus.3706
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