Second Re-irradiation of Brain Metastases: A Review of Studies Involving Stereotactic Radiosurgery

Due to advances in the systemic and local treatment, e.g., targeted therapy, immune checkpoint inhibitors, and stereotactic radiotherapy, an increasing proportion of patients with brain metastases now survive for several years. However, long-term survival is not synonymous to permanent local control in the brain. Both local and distant brain relapse sometimes necessitate additional radiotherapy to prevent death from neurologic causes. Prescribing more than two courses of radiotherapy to the same target volume or, in this case, brain metastasis, is a controversial approach. The present review summarizes the results of clinical studies, that included patients treated with whole-brain radiotherapy (WBRT) and two courses of stereotactic radiotherapy to the same, locally recurrent metastasis, and with two courses of WBRT and an additional stereotactic radiotherapy.