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Prognostic Role of Tenascin-C for Cancer Outcome: A Meta-Analysis

BACKGROUND: The prognostic value of tenascin-C in different types of cancers remains controversial. To clarify its prognostic value on overall survival rates, we have conducted a meta-analysis to quantitatively assess the prognostic roles of tenascin-C for patients with cancer. METHODS: We systemati...

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Autores principales: Ming, Xinliang, Qiu, Shili, Liu, Xuefang, Li, Shuo, Wang, Yingchao, Zhu, Man, Li, Nandi, Luo, Ping, Liang, Chunzi, Tu, Jiancheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373989/
https://www.ncbi.nlm.nih.gov/pubmed/30803361
http://dx.doi.org/10.1177/1533033818821106
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author Ming, Xinliang
Qiu, Shili
Liu, Xuefang
Li, Shuo
Wang, Yingchao
Zhu, Man
Li, Nandi
Luo, Ping
Liang, Chunzi
Tu, Jiancheng
author_facet Ming, Xinliang
Qiu, Shili
Liu, Xuefang
Li, Shuo
Wang, Yingchao
Zhu, Man
Li, Nandi
Luo, Ping
Liang, Chunzi
Tu, Jiancheng
author_sort Ming, Xinliang
collection PubMed
description BACKGROUND: The prognostic value of tenascin-C in different types of cancers remains controversial. To clarify its prognostic value on overall survival rates, we have conducted a meta-analysis to quantitatively assess the prognostic roles of tenascin-C for patients with cancer. METHODS: We systematically searched all published studies about the role of tenascin-C in cancers on PubMed, Web of Science, Cochrane Library, and Embase. The pooled hazard ratio with 95% confidence intervals was used to analyze the association between tenascin-C expression level and overall survival of patients with cancer. The pooled odds ratio with 95% confidence intervals was used to investigate the association between tenascin-C expression level and clinicopathologic features of patients with cancer. Trial sequential analysis was performed to obtain the required information size. RESULTS: In this meta-analysis, 18 studies including 2732 patients were incorporated. The pooled hazard ratio of 18 trials was 1.73 (95% confidence interval: 1.29-2.32, P < .001) for overall survival, suggesting that elevated tenascin-C expression strongly predicted poor prognosis among patients with various cancers. Simultaneously, elevated tenascin-C expression was also significantly associated with lymph node metastasis (odds ratio = 2.42, 95% confidence interval: 1.79-3.26, P < .001). However, no significant correlation was observed between the tenascin-C expression and distant metastasis (odds ratio = 1.72, 95% confidence interval: 0.86-3.44, P = .127). CONCLUSIONS: Tenascin-C is considered as a promising unfavorable prognostic factor in human cancers. Likewise, tenascin-C can be used as a monitoring indicator for poor prognosis in a wide range of cancers.
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spelling pubmed-63739892019-02-20 Prognostic Role of Tenascin-C for Cancer Outcome: A Meta-Analysis Ming, Xinliang Qiu, Shili Liu, Xuefang Li, Shuo Wang, Yingchao Zhu, Man Li, Nandi Luo, Ping Liang, Chunzi Tu, Jiancheng Technol Cancer Res Treat Original Article BACKGROUND: The prognostic value of tenascin-C in different types of cancers remains controversial. To clarify its prognostic value on overall survival rates, we have conducted a meta-analysis to quantitatively assess the prognostic roles of tenascin-C for patients with cancer. METHODS: We systematically searched all published studies about the role of tenascin-C in cancers on PubMed, Web of Science, Cochrane Library, and Embase. The pooled hazard ratio with 95% confidence intervals was used to analyze the association between tenascin-C expression level and overall survival of patients with cancer. The pooled odds ratio with 95% confidence intervals was used to investigate the association between tenascin-C expression level and clinicopathologic features of patients with cancer. Trial sequential analysis was performed to obtain the required information size. RESULTS: In this meta-analysis, 18 studies including 2732 patients were incorporated. The pooled hazard ratio of 18 trials was 1.73 (95% confidence interval: 1.29-2.32, P < .001) for overall survival, suggesting that elevated tenascin-C expression strongly predicted poor prognosis among patients with various cancers. Simultaneously, elevated tenascin-C expression was also significantly associated with lymph node metastasis (odds ratio = 2.42, 95% confidence interval: 1.79-3.26, P < .001). However, no significant correlation was observed between the tenascin-C expression and distant metastasis (odds ratio = 1.72, 95% confidence interval: 0.86-3.44, P = .127). CONCLUSIONS: Tenascin-C is considered as a promising unfavorable prognostic factor in human cancers. Likewise, tenascin-C can be used as a monitoring indicator for poor prognosis in a wide range of cancers. SAGE Publications 2019-01-06 /pmc/articles/PMC6373989/ /pubmed/30803361 http://dx.doi.org/10.1177/1533033818821106 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Article
Ming, Xinliang
Qiu, Shili
Liu, Xuefang
Li, Shuo
Wang, Yingchao
Zhu, Man
Li, Nandi
Luo, Ping
Liang, Chunzi
Tu, Jiancheng
Prognostic Role of Tenascin-C for Cancer Outcome: A Meta-Analysis
title Prognostic Role of Tenascin-C for Cancer Outcome: A Meta-Analysis
title_full Prognostic Role of Tenascin-C for Cancer Outcome: A Meta-Analysis
title_fullStr Prognostic Role of Tenascin-C for Cancer Outcome: A Meta-Analysis
title_full_unstemmed Prognostic Role of Tenascin-C for Cancer Outcome: A Meta-Analysis
title_short Prognostic Role of Tenascin-C for Cancer Outcome: A Meta-Analysis
title_sort prognostic role of tenascin-c for cancer outcome: a meta-analysis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373989/
https://www.ncbi.nlm.nih.gov/pubmed/30803361
http://dx.doi.org/10.1177/1533033818821106
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