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Prognostic Role of Tenascin-C for Cancer Outcome: A Meta-Analysis
BACKGROUND: The prognostic value of tenascin-C in different types of cancers remains controversial. To clarify its prognostic value on overall survival rates, we have conducted a meta-analysis to quantitatively assess the prognostic roles of tenascin-C for patients with cancer. METHODS: We systemati...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373989/ https://www.ncbi.nlm.nih.gov/pubmed/30803361 http://dx.doi.org/10.1177/1533033818821106 |
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author | Ming, Xinliang Qiu, Shili Liu, Xuefang Li, Shuo Wang, Yingchao Zhu, Man Li, Nandi Luo, Ping Liang, Chunzi Tu, Jiancheng |
author_facet | Ming, Xinliang Qiu, Shili Liu, Xuefang Li, Shuo Wang, Yingchao Zhu, Man Li, Nandi Luo, Ping Liang, Chunzi Tu, Jiancheng |
author_sort | Ming, Xinliang |
collection | PubMed |
description | BACKGROUND: The prognostic value of tenascin-C in different types of cancers remains controversial. To clarify its prognostic value on overall survival rates, we have conducted a meta-analysis to quantitatively assess the prognostic roles of tenascin-C for patients with cancer. METHODS: We systematically searched all published studies about the role of tenascin-C in cancers on PubMed, Web of Science, Cochrane Library, and Embase. The pooled hazard ratio with 95% confidence intervals was used to analyze the association between tenascin-C expression level and overall survival of patients with cancer. The pooled odds ratio with 95% confidence intervals was used to investigate the association between tenascin-C expression level and clinicopathologic features of patients with cancer. Trial sequential analysis was performed to obtain the required information size. RESULTS: In this meta-analysis, 18 studies including 2732 patients were incorporated. The pooled hazard ratio of 18 trials was 1.73 (95% confidence interval: 1.29-2.32, P < .001) for overall survival, suggesting that elevated tenascin-C expression strongly predicted poor prognosis among patients with various cancers. Simultaneously, elevated tenascin-C expression was also significantly associated with lymph node metastasis (odds ratio = 2.42, 95% confidence interval: 1.79-3.26, P < .001). However, no significant correlation was observed between the tenascin-C expression and distant metastasis (odds ratio = 1.72, 95% confidence interval: 0.86-3.44, P = .127). CONCLUSIONS: Tenascin-C is considered as a promising unfavorable prognostic factor in human cancers. Likewise, tenascin-C can be used as a monitoring indicator for poor prognosis in a wide range of cancers. |
format | Online Article Text |
id | pubmed-6373989 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-63739892019-02-20 Prognostic Role of Tenascin-C for Cancer Outcome: A Meta-Analysis Ming, Xinliang Qiu, Shili Liu, Xuefang Li, Shuo Wang, Yingchao Zhu, Man Li, Nandi Luo, Ping Liang, Chunzi Tu, Jiancheng Technol Cancer Res Treat Original Article BACKGROUND: The prognostic value of tenascin-C in different types of cancers remains controversial. To clarify its prognostic value on overall survival rates, we have conducted a meta-analysis to quantitatively assess the prognostic roles of tenascin-C for patients with cancer. METHODS: We systematically searched all published studies about the role of tenascin-C in cancers on PubMed, Web of Science, Cochrane Library, and Embase. The pooled hazard ratio with 95% confidence intervals was used to analyze the association between tenascin-C expression level and overall survival of patients with cancer. The pooled odds ratio with 95% confidence intervals was used to investigate the association between tenascin-C expression level and clinicopathologic features of patients with cancer. Trial sequential analysis was performed to obtain the required information size. RESULTS: In this meta-analysis, 18 studies including 2732 patients were incorporated. The pooled hazard ratio of 18 trials was 1.73 (95% confidence interval: 1.29-2.32, P < .001) for overall survival, suggesting that elevated tenascin-C expression strongly predicted poor prognosis among patients with various cancers. Simultaneously, elevated tenascin-C expression was also significantly associated with lymph node metastasis (odds ratio = 2.42, 95% confidence interval: 1.79-3.26, P < .001). However, no significant correlation was observed between the tenascin-C expression and distant metastasis (odds ratio = 1.72, 95% confidence interval: 0.86-3.44, P = .127). CONCLUSIONS: Tenascin-C is considered as a promising unfavorable prognostic factor in human cancers. Likewise, tenascin-C can be used as a monitoring indicator for poor prognosis in a wide range of cancers. SAGE Publications 2019-01-06 /pmc/articles/PMC6373989/ /pubmed/30803361 http://dx.doi.org/10.1177/1533033818821106 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Article Ming, Xinliang Qiu, Shili Liu, Xuefang Li, Shuo Wang, Yingchao Zhu, Man Li, Nandi Luo, Ping Liang, Chunzi Tu, Jiancheng Prognostic Role of Tenascin-C for Cancer Outcome: A Meta-Analysis |
title | Prognostic Role of Tenascin-C for Cancer Outcome: A Meta-Analysis |
title_full | Prognostic Role of Tenascin-C for Cancer Outcome: A Meta-Analysis |
title_fullStr | Prognostic Role of Tenascin-C for Cancer Outcome: A Meta-Analysis |
title_full_unstemmed | Prognostic Role of Tenascin-C for Cancer Outcome: A Meta-Analysis |
title_short | Prognostic Role of Tenascin-C for Cancer Outcome: A Meta-Analysis |
title_sort | prognostic role of tenascin-c for cancer outcome: a meta-analysis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373989/ https://www.ncbi.nlm.nih.gov/pubmed/30803361 http://dx.doi.org/10.1177/1533033818821106 |
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