Cargando…

A Collection of Single-Domain Antibodies that Crowd Ricin Toxin’s Active Site

In this report, we used hydrogen exchange-mass spectrometry (HX-MS) to identify the epitopes recognized by 21 single-domain camelid antibodies (V(H)Hs) directed against the ribosome-inactivating subunit (RTA) of ricin toxin, a biothreat agent of concern to military and public health authorities. The...

Descripción completa

Detalles Bibliográficos
Autores principales:	Angalakurthi, Siva Krishna, Vance, David J., Rong, Yinghui, Nguyen, Chi My Thi, Rudolph, Michael J., Volkin, David, Middaugh, C. Russell, Weis, David D., Mantis, Nicholas J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374049/ https://www.ncbi.nlm.nih.gov/pubmed/30775035 http://dx.doi.org/10.3390/antib7040045

Ejemplares similares

Single-domain antibodies neutralize ricin toxin intracellularly by blocking access to ribosomal P-stalk proteins
por: Czajka, Timothy F., et al.
Publicado: (2022)

Sub-Domains of Ricin’s B Subunit as Targets of Toxin Neutralizing and Non-Neutralizing Monoclonal Antibodies
por: Yermakova, Anastasiya, et al.
Publicado: (2012)

Spatial location of neutralizing and non-neutralizing B cell epitopes on domain 1 of ricin toxin’s binding subunit
por: Rong, Yinghui, et al.
Publicado: (2017)

Sites of vulnerability on ricin B chain revealed through epitope mapping of toxin-neutralizing monoclonal antibodies
por: Vance, David J., et al.
Publicado: (2020)

Differential Neutralizing Activities of a Single Domain Camelid Antibody (V(H)H) Specific for Ricin Toxin’s Binding Subunit (RTB)
por: Herrera, Cristina, et al.
Publicado: (2014)

Sensitivity of Kupffer cells and liver sinusoidal endothelial cells to ricin toxin and ricin toxin–Ab complexes
por: Mooney, Bridget, et al.
Publicado: (2019)

A Supercluster of Neutralizing Epitopes at the Interface of Ricin’s Enzymatic (RTA) and Binding (RTB) Subunits
por: Poon, Amanda Y., et al.
Publicado: (2017)

Antibody-Mediated Inhibition of Ricin Toxin Retrograde Transport
por: Yermakova, Anastasiya, et al.
Publicado: (2014)

Differential ER stress as a driver of cell fate following ricin toxin exposure
por: Peterson‐Reynolds, Claire, et al.
Publicado: (2021)

Durable Immunity to Ricin Toxin Elicited by a Thermostable, Lyophilized Subunit Vaccine
por: Novak, Hayley, et al.
Publicado: (2021)

Role of the Mannose Receptor (CD206) in Innate Immunity to Ricin Toxin
por: Gage, Emily, et al.
Publicado: (2011)

A Bispecific Antibody Promotes Aggregation of Ricin Toxin on Cell Surfaces and Alters Dynamics of Toxin Internalization and Trafficking
por: Herrera, Cristina, et al.
Publicado: (2016)

Neutralizing Monoclonal Antibodies against Disparate Epitopes on Ricin Toxin’s Enzymatic Subunit Interfere with Intracellular Toxin Transport
por: Yermakova, Anastasiya, et al.
Publicado: (2016)

A Humanized Monoclonal Antibody Cocktail to Prevent Pulmonary Ricin Intoxication
por: Rong, Yinghui, et al.
Publicado: (2020)

Mucoricin is a Ricin-Like Toxin that is Critical for the Pathogenesis of Mucormycosis
por: Soliman, Sameh S. M., et al.
Publicado: (2021)

Introduction to the Toxins Special Issue “Ricin Toxins”
por: Tumer, Nilgun E.
Publicado: (2019)

Neutralising Antibodies against Ricin Toxin
por: Prigent, Julie, et al.
Publicado: (2011)

Serum antibody profiling identifies vaccine-induced correlates of protection against aerosolized ricin toxin in rhesus macaques
por: Roy, Chad J., et al.
Publicado: (2022)

Identification of Small Molecules That Suppress Ricin-Induced Stress-Activated Signaling Pathways
por: Wahome, Paul G., et al.
Publicado: (2012)

Ricin Toxin Activates the NALP3 Inflammasome
por: Lindauer, Meghan, et al.
Publicado: (2010)

Intracellular Transport and Cytotoxicity of the Protein Toxin Ricin
por: Sowa-Rogozińska, Natalia, et al.
Publicado: (2019)

Passive immunization with an extended half-life monoclonal antibody protects Rhesus macaques against aerosolized ricin toxin
por: Roy, Chad J., et al.
Publicado: (2020)

Influence of environmental conditions on the attenuation of ricin toxin on surfaces
por: Wood, Joseph P., et al.
Publicado: (2018)

Ricin: An Ancient Story for a Timeless Plant Toxin
por: Polito, Letizia, et al.
Publicado: (2019)

Development of a candidate stabilizing formulation for bulk storage of a double mutant heat labile toxin (dmLT) protein based adjuvant
por: Toprani, Vishal M., et al.
Publicado: (2017)

Adapting Yeast as Model to Study Ricin Toxin A Uptake and Trafficking(‡)
por: Becker, Björn, et al.
Publicado: (2011)

Ligand based virtual screening to find novel inhibitors against plant toxin Ricin by using the ZINC database
por: Mishra, Vinita, et al.
Publicado: (2011)

Clinical and Pathological Findings Associated with Aerosol Exposure of Macaques to Ricin Toxin
por: Pincus, Seth H., et al.
Publicado: (2015)

Structural Characterization and Physicochemical Stability Profile of a Double Mutant Heat Labile Toxin Protein Based Adjuvant
por: Toprani, Vishal M., et al.
Publicado: (2017)

TNF Family Cytokines Induce Distinct Cell Death Modalities in the A549 Human Lung Epithelial Cell Line when Administered in Combination with Ricin Toxin
por: Hodges, Alexa L., et al.
Publicado: (2019)

Neutralization of Typhoid Toxin by Alpaca-Derived, Single-Domain Antibodies Targeting the PltB and CdtB Subunits
por: Dulal, Hari P., et al.
Publicado: (2022)

Erratum: Differences in Ribosome Binding and Sarcin/Ricin Loop Depurination by Shiga and Ricin Holotoxins. Toxins 2017, 9, 133
por: Editorial Office, Toxins
Publicado: (2018)

Role of Fc in Antibody-Mediated Protection from Ricin Toxin
por: Pincus, Seth. H., et al.
Publicado: (2014)

Bithionol blocks pathogenicity of bacterial toxins, ricin, and Zika virus
por: Leonardi, William, et al.
Publicado: (2016)

Ricin and Shiga Toxins: Effects on Host Cell Signal Transduction
por: Jandhyala, Dakshina M., et al.
Publicado: (2011)

Autophagic Degradation Is Involved in Cell Protection against Ricin Toxin
por: Wu, Yu, et al.
Publicado: (2023)

Slaying SARS-CoV-2 One (Single-domain) Antibody at a Time
por: Czajka, Timothy F., et al.
Publicado: (2021)

Recombinant ricin toxin A chain cytotoxicity against carcinoembryonic antigen expressing tumour cells mediated by a bispecific monoclonal antibody and its potentiation by ricin toxin B chain.
por: Embleton, M. J., et al.
Publicado: (1991)

Hydrogen exchange mass spectrometry reveals protein interfaces and distant dynamic coupling effects during the reversible self-association of an IgG1 monoclonal antibody
por: Arora, Jayant, et al.
Publicado: (2015)

Heterogeneous response of individual multicellular tumour spheroids to immunotoxins and ricin toxin.
por: Chignola, R., et al.
Publicado: (1995)

Cannot write session to /tmp/vufind_sessions/sess_0bb3frid3em0clvrilcjs7h62s