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A new painkiller nanomedicine to bypass the blood-brain barrier and the use of morphine

The clinical use of endogenous neuropeptides has historically been limited due to pharmacokinetic issues, including plasma stability and blood-brain barrier permeability. In this study, we show that the rapidly metabolized Leu-enkephalin (LENK) neuropeptide may become pharmacologically efficient owi...

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Detalles Bibliográficos
Autores principales:	Feng, Jiao, Lepetre-Mouelhi, Sinda, Gautier, Anne, Mura, Simona, Cailleau, Catherine, Coudore, François, Hamon, Michel, Couvreur, Patrick
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374102/ https://www.ncbi.nlm.nih.gov/pubmed/30788432 http://dx.doi.org/10.1126/sciadv.aau5148

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