Rapid depletion of ESCRT protein Vps4 underlies injury-induced autophagic impediment and Wallerian degeneration

Injured axons undergo a controlled, self-destruction process, known as Wallerian degeneration. However, the underlying mechanism remains elusive. Using the Drosophila wing nerve as a model, we identify the ESCRT component Vps4 as a previously unidentified essential gene for axonal integrity. Up-regu...

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Detalles Bibliográficos
Autores principales: Wang, Haiqiong, Wang, Xuejie, Zhang, Kai, Wang, Qingyao, Cao, Xu, Wang, Zhao, Zhang, Shuang, Li, Ang, Liu, Kai, Fang, Yanshan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374107/
https://www.ncbi.nlm.nih.gov/pubmed/30788439
http://dx.doi.org/10.1126/sciadv.aav4971

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