Cargando…

Leukemia Inhibitory Factor Functions in Parallel with Interleukin-6 to Promote Ovarian Cancer Growth

Ovarian carcinoma-associated mesenchymal stem cells (CA-MSC) produce not only high levels of IL6 but also the related cytokine leukemia inhibitory factor (LIF). Interleukin 6 (IL6) mediated activation of STAT3 is implicated as a critical therapeutic target for cancer therapy. Less is known about the...

Descripción completa

Detalles Bibliográficos
Autores principales:	McLean, Karen, Tan, Lijun, Bolland, Danielle E., Coffman, Lan G., Peterson, Luke F., Talpaz, Moshe, Neamati, Nouri, Buckanovich, Ronald J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374186/ https://www.ncbi.nlm.nih.gov/pubmed/30305729 http://dx.doi.org/10.1038/s41388-018-0523-6

Ejemplares similares

BMPs morph into new roles in ovarian cancer
por: McLean, Karen, et al.
Publicado: (2013)

Human carcinoma-associated mesenchymal stem cells promote ovarian cancer chemotherapy resistance via a BMP4/HH signaling loop
por: Coffman, Lan G., et al.
Publicado: (2016)

Clinicopathological significance of endoplasmic reticulum stress proteins in ovarian carcinoma
por: Samanta, Soma, et al.
Publicado: (2020)

Expression of protein disulfide isomerase family members correlates with tumor progression and patient survival in ovarian cancer
por: Samanta, Soma, et al.
Publicado: (2017)

The DEK Oncoprotein Functions in Ovarian Cancer Growth and Survival()
por: Hacker, Kari E, et al.
Publicado: (2018)

Carcinoma-Associated Mesenchymal Stem/Stromal Cells: Architects of the Pro-tumorigenic Tumor Microenvironment
por: Frisbie, Len, et al.
Publicado: (2022)

CDK4/6 inhibition as maintenance and combination therapy for high grade serous ovarian cancer
por: Iyengar, Mangala, et al.
Publicado: (2018)

CD105 Is Expressed in Ovarian Cancer Precursor Lesions and Is Required for Metastasis to the Ovary
por: Bai, Shoumei, et al.
Publicado: (2019)

Ovarian Carcinoma‐Associated Mesenchymal Stem Cells Arise from Tissue‐Specific Normal Stroma
por: Coffman, Lan G., et al.
Publicado: (2018)

Inhibition of Tumor Microenvironment Cytokine Signaling Sensitizes Ovarian Cancer Cells to Antiestrogen Therapy
por: Tan, Lijun, et al.
Publicado: (2022)

Carcinoma-Associated Mesenchymal Stem Cells Promote Chemoresistance in Ovarian Cancer Stem Cells via PDGF Signaling
por: Raghavan, Shreya, et al.
Publicado: (2020)

Shifting the Soil: Metformin Treatment Decreases the Protumorigenic Tumor Microenvironment in Epithelial Ovarian Cancer
por: Taylor, Sarah E., et al.
Publicado: (2022)

Phase I trial of ribociclib with platinum chemotherapy in ovarian cancer
por: Coffman, Lan G., et al.
Publicado: (2022)

Dasatinib dose management for the treatment of chronic myeloid leukemia
por: Talpaz, Moshe, et al.
Publicado: (2018)

Multi-omics profiling reveals key signaling pathways in ovarian cancer controlled by STAT3
por: Lu, Tiangong, et al.
Publicado: (2019)

Tumor necrosis factor related apoptosis inducing ligand (TRAIL) regulates deubiquitinase USP5 in tumor cells
por: Potu, Harish, et al.
Publicado: (2019)

Identifying alemtuzumab as an anti-myeloid cell antiangiogenic therapy for the treatment of ovarian cancer
por: Pulaski, Heather L, et al.
Publicado: (2009)

Bevacizumab for the Treatment of Non-Resectable Pseudomyxoma peritonei Associated with Mucinous Ovarian Tumor of Low Malignant Potential – A Comparison of Two Cases
por: Winer, Ira, et al.
Publicado: (2009)

SETDB1 mediated histone H3 lysine 9 methylation suppresses MLL-fusion target expression and leukemic transformation
por: Ropa, James, et al.
Publicado: (2019)

Downregulation of SOX2 by inhibition of Usp9X induces apoptosis in melanoma
por: Potu, Harish, et al.
Publicado: (2021)

Raltegravir: The evidence of its therapeutic value in HIV-1 infection
por: Ramkumar, Kavya, et al.
Publicado: (2010)

Usp5 links suppression of p53 and FAS levels in melanoma to the BRAF pathway
por: Potu, Harish, et al.
Publicado: (2014)

Tumor-derived interleukin-1α and leukemia inhibitory factor promote extramedullary hematopoiesis
por: Barisas, Derek A. G., et al.
Publicado: (2023)

Immunotherapy Advances for Epithelial Ovarian Cancer
por: Hartnett, Erin G., et al.
Publicado: (2020)

Integrin Targeted Therapeutics
por: Millard, Melissa, et al.
Publicado: (2011)

Role of the CXCL8-CXCR1/2 Axis in Cancer and Inflammatory Diseases
por: Ha, Helen, et al.
Publicado: (2017)

2,3-Dihydroquinazolin-4(1H)-one as a privileged scaffold in drug design
por: Badolato, Mariateresa, et al.
Publicado: (2018)

Up-regulation of hypoxia-inducible factor antisense as a novel approach to treat ovarian cancer
por: Lu, Tiangong, et al.
Publicado: (2020)

Fedratinib, a newly approved treatment for patients with myeloproliferative neoplasm-associated myelofibrosis
por: Talpaz, Moshe, et al.
Publicado: (2020)

PR1-Specific T Cells Are Associated with Unmaintained Cytogenetic Remission of Chronic Myelogenous Leukemia After Interferon Withdrawal
por: Kanodia, Shreya, et al.
Publicado: (2010)

Intestinal Radiation Protection and Mitigation by Second-Generation Probiotic Lactobacillus-reuteri Engineered to Deliver Interleukin-22
por: Espinal, Alexis, et al.
Publicado: (2022)

Mechanistic Evaluation of a Novel Small Molecule Targeting Mitochondria in Pancreatic Cancer Cells
por: Shabaik, Yumna H., et al.
Publicado: (2013)

Epigenomic Reprogramming toward Mesenchymal-Epithelial Transition in Ovarian-Cancer-Associated Mesenchymal Stem Cells Drives Metastasis
por: Fan, Huihui, et al.
Publicado: (2020)

Raltegravir, elvitegravir, and metoogravir: the birth of "me-too" HIV-1 integrase inhibitors
por: Serrao, Erik, et al.
Publicado: (2009)

Raltegravir, elvitegravir, and metoogravir: the birth of "me-too" HIV-1 integrase inhibitors
por: Serrao, Erik, et al.
Publicado: (2009)

Analysis of Apoptosis in Cultured Human Vitrified Ovarian Tissue in the Presence of Leukemia Inhibitory Factor
por: Abdollahi, Maasoume, et al.
Publicado: (2018)

Neuromodulatory control of inhibitory network arborization in the developing postnatal neocortex
por: Steinecke, André, et al.
Publicado: (2022)

Ruxolitinib is effective in patients with intermediate-1 risk myelofibrosis: a summary of recent evidence
por: Harrison, Claire N., et al.
Publicado: (2016)

Combination of Estradiol with Leukemia Inhibitory Factor Stimulates Granulosa Cells Differentiation into Oocyte-Like Cells
por: Yousefi, Soudabe, et al.
Publicado: (2021)

TNF-α Affects Human Cortical Neural Progenitor Cell Differentiation through the Autocrine Secretion of Leukemia Inhibitory Factor
por: Lan, Xiqian, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_qsi6i04s9fve4nl6rh47e3alib