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Adenosine A2A Receptor Stimulation Inhibits TCR-Induced Notch1 Activation in CD8+T-Cells

Notch receptors signaling is required for optimal T-cell activation and function. T-cell receptor (TCR) engagement can activate Notch receptors in T-cells in a ligand-independent fashion. In this study, we examined the role of adenosine A2A receptor (A2AR) signaling pathway in regulating the activit...

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Detalles Bibliográficos
Autores principales:	Sorrentino, Claudia, Hossain, Fokhrul, Rodriguez, Paulo C., Sierra, Rosa A., Pannuti, Antonio, Hatfield, Stephen, Osborne, Barbara A., Minter, Lisa M., Miele, Lucio, Morello, Silvana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374329/ https://www.ncbi.nlm.nih.gov/pubmed/30792717 http://dx.doi.org/10.3389/fimmu.2019.00162

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