A meiosis-specific BRCA2 binding protein recruits recombinases to DNA double-strand breaks to ensure homologous recombination

Homologous recombination (HR) repairs DNA double-strand breaks (DSBs) to maintain genomic integrity. Recombinase recruited to the DSBs by the mediator protein BRCA2 catalyzes the homology-directed repair. During meiotic HR, programmed DSBs are introduced genome-wide but their repair mechanisms, incl...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Jingjing, Fujiwara, Yasuhiro, Yamamoto, Shohei, Shibuya, Hiroki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374363/
https://www.ncbi.nlm.nih.gov/pubmed/30760716
http://dx.doi.org/10.1038/s41467-019-08676-2

Ejemplares similares

Ejemplares similares