Longitudinal HIV sequencing reveals reservoir expression leading to decay which is obscured by clonal expansion

After initiating antiretroviral therapy (ART), a rapid decline in HIV viral load is followed by a long period of undetectable viremia. Viral outgrowth assay suggests the reservoir continues to decline slowly. Here, we use full-length sequencing to longitudinally study the proviral landscape of four...

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Detalles Bibliográficos
Autores principales: Pinzone, Marilia Rita, VanBelzen, D. Jake, Weissman, Sam, Bertuccio, Maria Paola, Cannon, LaMont, Venanzi-Rullo, Emmanuele, Migueles, Stephen, Jones, R. Brad, Mota, Talia, Joseph, Sarah B., Groen, Kevin, Pasternak, Alexander O., Hwang, Wei-Ting, Sherman, Brad, Vourekas, Anastasios, Nunnari, Giuseppe, O’Doherty, Una
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374386/
https://www.ncbi.nlm.nih.gov/pubmed/30760706
http://dx.doi.org/10.1038/s41467-019-08431-7

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