Highly Efficient Transgenesis in Ferrets Using CRISPR/Cas9-Mediated Homology-Independent Insertion at the ROSA26 Locus

The domestic ferret (Mustela putorius furo) has proven to be a useful species for modeling human genetic and infectious diseases of the lung and brain. However, biomedical research in ferrets has been hindered by the lack of rapid and cost-effective methods for genome engineering. Here, we utilized...

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Detalles Bibliográficos
Autores principales: Yu, Miao, Sun, Xingshen, Tyler, Scott R., Liang, Bo, Swatek, Anthony M., Lynch, Thomas J., He, Nan, Yuan, Feng, Feng, Zehua, Rotti, Pavana G., Choi, Soon H., Shahin, Weam, Liu, Xiaoming, Yan, Ziying, Engelhardt, John F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374392/
https://www.ncbi.nlm.nih.gov/pubmed/30760763
http://dx.doi.org/10.1038/s41598-018-37192-4

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